Evidence map›Paper›PMID 33260607›Full record

ArticleInternational journal of molecular sciences2020

Insights into Transcriptional Repression of the Homologous Toxin-Antitoxin Cassettes

Barbara Kędzierska, Katarzyna Potrykus, Agnieszka Szalewska-Pałasz, Beata Wodzikowska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Minigene as a Novel Regulatory Element in Toxin-Antitoxin Systems.International journal of molecular sciences · 2021
    Article
  5. Interactions of theMicroorganisms · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Barbara KędzierskaDepartment of Bacterial Molecular Genetics, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
Katarzyna PotrykusDepartment of Bacterial Molecular Genetics, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.ORCID 0000-0002-4902-3348
Agnieszka Szalewska-PałaszDepartment of Bacterial Molecular Genetics, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.ORCID 0000-0001-8013-4057
Beata WodzikowskaDepartment of Bacterial Molecular Genetics, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
University of Gdańsk · PL

Funding

Polish Ministry of Science and Higher Education N N301 251936Statutory Funds of the University of Gdansk 531-L140-D694-19
6 · The paper itself

Abstract

Transcriptional repression is a mechanism which enables effective gene expression switch off. The activity of most of type II toxin-antitoxin (TA) cassettes is controlled in this way. These cassettes undergo negative autoregulation by the TA protein complex which binds to the promoter/operator sequence and blocks transcription initiation of the TA operon. Precise and tight control of this process is vital to avoid uncontrolled expression of the toxin component. Here, we employed a series of in vivo and in vitro experiments to establish the molecular basis for previously observed differences in transcriptional activity and repression levels of the

Indexed as

Toxin-Antitoxin SystemsBacterial ToxinsBase SequenceDNA, BacterialEscherichia coliEscherichia coli ProteinsModels, BiologicalOperator Regions, GeneticPromoter Regions, GeneticRepressor ProteinsTranscription, GeneticBacterial ToxinsDNA, BacterialEscherichia coli ProteinsRepressor ProteinsYefM protein, E coliYoeB protein, E coliAxe-Txehomologous toxin-antitoxintranscription repressionYefM-YoeB

Identifiers

PMID33260607
PMCPMC7730913
OpenAlexW3107668135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.