Evidence map›Paper›PMID 33260551›Full record

ReviewMolecules (Basel, Switzerland)2020

Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications.

Carissa M Lloyd, Neil Colgin, Steven L Cobb

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The Duality of Dioxolanyl Radicals towards C-C Bond Construction.Synlett : accounts and rapid communications in synthetic organic chemistry · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carissa M LloydDepartment of Chemistry, Faculty of Science, Durham University, Durham DH1 3LE, UK.
Neil ColginCambridge Research Biochemicals, 17-18 Belasis Court, Belasis Hall Technology Park, Billingham, Cleveland TS23 4AZ, UK.
Steven L CobbDepartment of Chemistry, Faculty of Science, Durham University, Durham DH1 3LE, UK.

Funding

Cambridge Research Biochemicals Ltd and European Development Agency Funding (ERDF - Intensive Industrial Innovation Programme) 34R17P02148
6 · The paper itself

Abstract

Peptidyl mono-fluoromethyl ketones (FMKs) are a class of biologically active molecules that show potential as both protease inhibitors for the treatment of a range of diseases and as chemical probes for the interrogation of cellular processes. This review describes the current solid- and solution-phase routes employed for the synthesis of peptidyl mono-FMKs. In addition, it provides a brief overview of some of the key applications of FMKs in the fields of chemical biology and medicinal chemistry.

Indexed as

AnimalsChemistry, PharmaceuticalHumansKetonesPeptide FragmentsProtease InhibitorsKetonesPeptide FragmentsProtease Inhibitorsfluorinefluoromethyl ketonepeptidepeptide modificationpeptide synthesisprobetherapeutic

Identifiers

PMID33260551
PMCPMC7730879

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.