Evidence map›Paper›PMID 33260340›Full record

ArticleInternational journal of molecular sciences2020

Gold Nanopeanuts as Prospective Support for Cisplatin in Glioblastoma Nano-Chemo-Radiotherapy.

Joanna Depciuch, Justyna Miszczyk, Alexey Maximenko, Piotr M Zielinski, Kamila Rawojć, Agnieszka Panek, Pawel Olko, Magdalena Parlinska-Wojtan

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joanna DepciuchInstitute of Nuclear Physics Polish Academy of Sciences, 31-342 Krakow, Poland.ORCID 0000-0003-0168-1701
Justyna MiszczykInstitute of Nuclear Physics Polish Academy of Sciences, 31-342 Krakow, Poland.ORCID 0000-0001-7226-1750
Alexey MaximenkoInstitute of Nuclear Physics Polish Academy of Sciences, 31-342 Krakow, Poland.ORCID 0000-0003-2660-8105
Piotr M ZielinskiInstitute of Nuclear Physics Polish Academy of Sciences, 31-342 Krakow, Poland.
Kamila RawojćDepartment of Endocrinology, Nuclear Medicine Unit, The University Hospital, 31-501 Krakow, Poland.
Agnieszka PanekInstitute of Nuclear Physics Polish Academy of Sciences, 31-342 Krakow, Poland.ORCID 0000-0002-3162-2668
Pawel OlkoInstitute of Nuclear Physics Polish Academy of Sciences, 31-342 Krakow, Poland.ORCID 0000-0001-5554-8178
Magdalena Parlinska-WojtanInstitute of Nuclear Physics Polish Academy of Sciences, 31-342 Krakow, Poland.ORCID 0000-0001-5901-400X
Institute of Nuclear Physics, Polish Academy of Sciences · PLKrakow Cardiovascular Research Institute · PL

Funding

Horizon 2020 UE project entitled "INfraStructure in Proton International REsearch", INSPIRE 730983
6 · The paper itself

Abstract

Herein, we propose newly designed and synthesized gold nanopeanuts (Au NPes) as supports for cisplatin (cPt) immobilization, dedicated to combined glioblastoma nano-chemo-radiotherapy. Au NPes offer a large active surface, which can be used for drugs immobilization. Transmission electron microscopy (TEM) revealed that the size of the synthesized Au NPes along the longitudinal axis is ~60 nm, while along the transverse axis ~20 nm. Raman, thermogravimetric analysis (TGA) and differential scanning calorimetry (DCS) measurements showed, that the created nanosystem is stable up to a temperature of 110 °C. MTT assay revealed, that the highest cell mortality was observed for cell lines subjected to nano-chemo-radiotherapy (20-55%). Hence, Au NPes with immobilized cPt (cPt@AuNPes) are a promising nanosystem to improve the therapeutic efficiency of combined nano-chemo-radiotherapy.

Indexed as

Brain NeoplasmsCell Line, TumorCell SurvivalCisplatinGlioblastomaGoldHumansMetal NanoparticlesSpectrum Analysis, RamanCisplatinGoldbiomedical applicationgold nanopeanutsnew shapesupport

Identifiers

PMID33260340
PMCPMC7730046
OpenAlexW3108554645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.