SynthesisBJU international2021
Association of erectile dysfunction and cardiovascular disease: an umbrella review of systematic reviews and meta-analyses.
Synthesis in BJU international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Pooled it
- The impact of obesity and obstructive sleep apnea on vascular hemodynamics in men under 40: a 15-year retrospective cohort study.Sexual medicine · 2026Article
- The causal effect of family history of cardiovascular disease on erectile dysfunction: a randomized clinical study and Mendelian randomization study.Asian journal of andrology · 2026Article
- Erectile dysfunction in primary care: practice patterns, barriers, and opportunities-narrative review.Sexual medicine · 2026Review
- Reply to the Letter to the Editor: "Methodological Considerations Regarding the Combined Use of Erectile Dysfunction and Frontal QRS-T Angle for Predicting Coronary Artery Disease Severity".Anatolian journal of cardiology · 2026Article
- Erectile Dysfunction: A Comprehensive Review of Pathophysiology, Diagnosis and Contemporary Management.Medicina (Kaunas, Lithuania) · 2026Review
- Erectile and Clitoral Dysfunction as Harbingers of Cardiovascular Disease: A Perspective.Medicina (Kaunas, Lithuania) · 2026Review
- Genetic biomarkers associated with risk and therapeutic response in erectile dysfunction: a systematic review.Frontiers in pharmacology · 2026Review
- Article
- Association between erectile dysfunction and relative fat mass in adult men in the United States.Translational andrology and urology · 2025Article
- Erectile dysfunction increases the risk of stroke: evidence from NHANES and Mendelian randomization analysis.Translational andrology and urology · 2025Article
- The Impact of Glucagon-like Peptide-1 Receptor Agonists on Erectile Function: Friend or Foe?Biomolecules · 2025Review
- Article
- A Narrative Review of Independent Treatment Methods for ED: Assessment of the Effectiveness of Diet, Supplements, Pharmacotherapy, and Physiotherapy.Journal of clinical medicine · 2025Review
- Relationship between the risk of atherosclerotic cardiovascular disease and decreased functional bladder capacity.International urology and nephrology · 2025Article
- An L-shaped association between lymphocyte-to-monocyte ratio and erectile dysfunction in NHANES 2001-2004.Scientific reports · 2025Article
- Residual cholesterol is independently associated with arteriogenic erectile dysfunction: results from a multi-institutional study.Frontiers in endocrinology · 2025Article
- Association of erectile dysfunction and daily food thiamin intake among men in the USA.BMJ nutrition, prevention & health · 2025Article
- Exploring the bidirectional link between erectile dysfunction and 10-year cardiovascular risk in men with diabetes and hypertension.Scientific reports · 2024Observational
- Prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction.International journal of impotence research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo present an overall picture of the evidence regarding the association of erectile dysfunction (ED) with cardiovascular disease (CVD).
methodsSystematic reviews and meta-analyses that studied the association of ED with any CVD were included in this umbrella review. We did not restrict the population to a particular group or age. PubMed, Embase, the Joanna Briggs Institute (JBI) Database of Systematic Reviews and Implementation Reports, the Cochrane Database of Systematic Reviews, the Database of Abstracts of Reviews of Effects, and the PROSPERO register were searched to find relevant systematic reviews, with or without meta-analyses, from inception to April 2020. The JBI Checklist for Systematic Reviews and Research Syntheses was used for the critical appraisal. Only studies with acceptable quality were included. Two independent reviewers extracted the data using the JBI data extraction tool for qualitative and quantitative data extraction.
resultsThe summary estimate showed a higher risk of CVD (relative risk [RR] 1.45, 95% confidence interval [CI] 1.36-1.54; P < 0.001), coronary heart disease (RR 1.50, 95% CI 1.37-1.64; P < 0.001), cardiovascular-related mortality (RR 1.50, 95% CI 1.37-1.64; P < 0.001), all-cause mortality (RR 1.25, 95% CI 1.18-1.32; P < 0.001), myocardial infarction (RR 1.55, 95% CI 1.33-1.80; P < 0.001) and stroke (RR 1.36, 95% CI 1.26-1.46; P < 0.001) in patients with ED than in other patients.
conclusionsOur results confirm that ED is an independent predictor of CVD and their outcomes. ED and CVD are two presentations of the same physiological phenomenon. ED normally precedes symptomatic CVD, providing a window of opportunity for healthcare practitioners to screen and detect high-risk patients early to prevent avoidable morbidity and mortality.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.