Evidence map›Paper›PMID 33260113›Full record

ArticleMedical image analysis2021

Structured layer surface segmentation for retina OCT using fully convolutional regression networks.

Yufan He, Aaron Carass, Yihao Liu, Bruno M Jedynak, Sharon D Solomon, Shiv Saidha, Peter A Calabresi, Jerry L Prince

Abstract read
In one paragraph

Article in Medical image analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Unsupervised OCT Image Interpolation Using Deformable Registration and generative models.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026
    Article
  5. Optical Coherence Tomography Harmonization via Dual Diffusion Implicit Bridges.Proceedings of SPIE--the International Society for Optical Engineering · 2026
    Article
  6. Article
  7. ROQUS: a retinal OCT quality and usability score.Biomedical optics express · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yufan HeDepartment of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: yhe35@jhu.edu.
Aaron CarassDepartment of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Computer Science, The Johns Hopkins University, Baltimore, MD 21218, USA.
Yihao LiuDepartment of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.
Bruno M JedynakDepartment of Mathematics & Statistics, Portland State University, Portland, OR 97201, USA.
Sharon D SolomonWilmer Eye Institute, The Johns Hopkins University School of Medicine, MD 21287, USA.
Shiv SaidhaDepartment of Neurology, The Johns Hopkins University School of Medicine, MD 21287, USA.
Peter A CalabresiDepartment of Neurology, The Johns Hopkins University School of Medicine, MD 21287, USA.
Jerry L PrinceDepartment of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Computer Science, The Johns Hopkins University, Baltimore, MD 21218, USA.

Funding

Imaging Neurodegeneration in Multiple SclerosisR01NS082347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETER A CALABRESI, Shiv Saidha · 2013 to 2026
$7.0M
OCT and OCTA image processing for retinal assessment of people with MSR01EY032284 · NEI · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2021 to 2024
$1.8M
3D segmentation and registration of macular SD-OCT for application in MSR01EY024655 · NEI · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2014 to 2017
$1.6M
NEI NIH HHS R01 EY024655NEI NIH HHS R01 EY032284NINDS NIH HHS R01 NS082347
6 · The paper itself

Abstract

Optical coherence tomography (OCT) is a noninvasive imaging modality with micrometer resolution which has been widely used for scanning the retina. Retinal layers are important biomarkers for many diseases. Accurate automated algorithms for segmenting smooth continuous layer surfaces with correct hierarchy (topology) are important for automated retinal thickness and surface shape analysis. State-of-the-art methods typically use a two step process. Firstly, a trained classifier is used to label each pixel into either background and layers or boundaries and non-boundaries. Secondly, the desired smooth surfaces with the correct topology are extracted by graph methods (e.g., graph cut). Data driven methods like deep networks have shown great ability for the pixel classification step, but to date have not been able to extract structured smooth continuous surfaces with topological constraints in the second step. In this paper, we combine these two steps into a unified deep learning framework by directly modeling the distribution of the surface positions. Smooth, continuous, and topologically correct surfaces are obtained in a single feed forward operation. The proposed method was evaluated on two publicly available data sets of healthy controls and subjects with either multiple sclerosis or diabetic macular edema, and is shown to achieve state-of-the art performance with sub-pixel accuracy.

Indexed as

Diabetic RetinopathyMacular EdemaAlgorithmsHumansRetinaTomography, Optical CoherenceDeep learning segmentationRetina OCTSurface segmentation

Identifiers

PMID33260113
PMCPMC7855873

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.