ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021
Evolution and genetic diversity of SARS-CoV-2 in Africa using whole genome sequences.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 43 citations in OpenAlex.
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- SARS-CoV-2 drug resistance and therapeutic approaches.Heliyon · 2025Review
- Dynamics of SARS-CoV-2 variants in West Africa: Insights into genomic surveillance in resource-constrained settings.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2024Review
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- Genetic diversity and spread dynamics of SARS-CoV-2 variants present in African populations.Royal Society open science · 2024Article
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- Substitution spectra of SARS-CoV-2 genome from Pakistan reveals insights into the evolution of variants across the pandemic.Scientific reports · 2023Article
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- Genomic and Epidemiologic Surveillance of SARS-CoV-2 in the Pandemic Period: Sequencing Network of the Lazio Region, Italy.Viruses · 2023Article
- Evolution of the newest diagnostic methods for COVID-19: a Chinese perspective.Journal of Zhejiang University. Science. B · 2023Review
- COVID-19 relapse associated with SARS-CoV-2 evasion from CD4iScience · 2023Article
- Global landscape of SARS-CoV-2 mutations and conserved regions.Journal of translational medicine · 2023Article
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- SARS-CoV-2 Variants Identification: Overview of Molecular Existing Methods.Pathogens (Basel, Switzerland) · 2022Review
- A comprehensive genomic study, mutation screening, phylogenetic and statistical analysis of SARS-CoV-2 and its variant omicron among different countries.Journal of infection and public health · 2022Article
- A simulation of geographic distribution for the emergence of consequential SARS-CoV-2 variant lineages.Scientific reports · 2022Article
- Phylogenetic and genome-wide mutational analysis of SARS-CoV-2 strains circulating in Nigeria: no implications for attenuated COVID-19 outcomes.Osong public health and research perspectives · 2022Article
- Aloin isoforms (A and B) selectively inhibits proteolytic and deubiquitinating activity of papain like protease (PLpro) of SARS-CoV-2 in vitro.Scientific reports · 2022Article
- Molecular evolutionary characteristics of SARS-CoV-2 emerging in the United States.Journal of medical virology · 2022Article
- Whole genome sequencing analysis of SARS-CoV-2 from Malaysia: From alpha to Omicron.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ongoing SARS-CoV-2 pandemic was introduced into Africa on 14th February 2020 and has rapidly spread across the continent causing a severe public health crisis and mortality. We investigated the genetic diversity and evolution of this virus during the early outbreak months, between 14th February to 24th April 2020, using whole genome sequences.
methodsWe performed recombination analysis against closely related CoV strains, Bayesian time scaled phylogeny, and investigation of spike protein amino acid mutations.
resultsRecombination signals were observed between the Afr-SARS-CoV-2 sequences and reference sequences within the RdRPs and S genes. The evolutionary rate of the Afr-SARS-CoV-2 was 4.133 × 10
conclusionThis study has revealed a rapidly diversifying viral population with the G614G spike protein variant dominatinge advocate for up scaling NGS sequencing platforms across Africa to enhance surveillance and aid control effort of SARS-CoV-2 in Africa.
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