ArticleJournal of hepato-biliary-pancreatic sciences2021
A case-control emergency department-based analysis of acute pancreatitis in Covid-19: Results of the UMC-19-S
Article in Journal of hepato-biliary-pancreatic sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- COVID-19-Induced Acute Pancreatitis: Clinical Profiles, Outcomes, and Prognostic Indicators From a Global Review-Based Synthesis.Health science reports · 2025Article
- The outcomes of COVID-19 and acute pancreatitis: a systematic review and meta-analysis.Translational gastroenterology and hepatology · 2024Article
- Impact of COVID-19 in individuals with and without pre-existent digestive disorders with a particular focus on elderly patients.World journal of gastroenterology · 2023Review
- Review
- The Pancreas in Coronavirus Disease 2019 Infection.Gastroenterology clinics of North America · 2023Review
- Hyperlipidemia, COVID-19 and acute pancreatitis: A tale of three entities.The American journal of the medical sciences · 2022Review
- Review on acute pancreatitis attributed to COVID-19 infection.World journal of gastroenterology · 2022Review
- COVID-19 Infection Deteriorates the Clinical Condition and Outcomes of Acute Pancreatitis: A Meta-Analysis.Emergency medicine international · 2022Article
- Acute pancreatitis and COVID-19: a new target for infection?Einstein (Sao Paulo, Brazil) · 2022Review
- A case-control emergency department-based analysis of acute pancreatitis in Covid-19: Results of the UMC-19-SJournal of hepato-biliary-pancreatic sciences · 2021Article
- A case-control analysis of stroke in COVID-19 patients: Results of unusual manifestations of COVID-19-study 11.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021Article
- Association between acute pancreatitis and COVID-19 infection: What do we know?World journal of gastrointestinal surgery · 2021Review
- Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings.Gastroenterology research and practice · 2021Article
- The burden of acute pancreatitis on COVID-19 in the United States.Annals of gastroenterologyArticle
- Acute Pancreatitis with Colonic Pseudo-obstruction in a Patient with COVID-19.Case reports in gastroenterologyArticle
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26 authors.
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Abstract
background/purposeWe investigated the incidence, risk factors, clinical characteristics and outcomes of acute pancreatitis (AP) in patients with COVID-19 attending the emergency department (ED), before hospitalization.
methodsWe retrospectively reviewed all COVID patients diagnosed with AP in 62 Spanish EDs (20% of Spanish EDs, COVID-AP) during the COVID outbreak. We formed two control groups: COVID patients without AP (COVID-non-AP) and non-COVID patients with AP (non-COVID-AP). Unadjusted comparisons between cases and controls were performed regarding 59 baseline and clinical characteristics and four outcomes.
resultsWe identified 54 AP in 74 814 patients with COVID-19 attending the ED (frequency = 0.72‰, 95% CI = 0.54-0.94‰). This frequency was lower than in non-COVID patients (2231/1 388 879, 1.61‰, 95% CI = 1.54-1.67; OR = 0.44, 95% CI = 0.34-0.58). Etiology of AP was similar in both groups, being biliary origin in about 50%. Twenty-six clinical characteristics of COVID patients were associated with a higher risk of developing AP: abdominal pain (OR = 59.4, 95% CI = 23.7-149), raised blood amylase (OR = 31.8; 95% CI = 1.60-632) and vomiting (OR = 15.8, 95% CI = 6.69-37.2) being the strongest, and some inflammatory markers (C-reactive protein, procalcitonin, platelets, D-dimer) were more increased. Compared to non-COVID-AP, COVID-AP patients differed in 23 variables; the strongest ones related to COVID symptoms, but less abdominal pain was reported, pancreatic enzymes raise was lower, and severity (estimated by BISAP and SOFA score at ED arrival) was higher. The in-hospital mortality (adjusted for age and sex) of COVID-AP did not differ from COVID-non-AP (OR = 1.12, 95% CI = 0.45-245) but was higher than non-COVID-AP (OR = 2.46, 95% CI = 1.35-4.48).
conclusionsAcute pancreatitis as presenting form of COVID-19 in the ED is unusual (<1‰ cases). Some clinically distinctive characteristics are present compared to the remaining COVID patients and can help to identify this unusual manifestation. In-hospital mortality of COVID-AP does not differ from COVID-non-AP but is higher than non-COVID-AP, and the higher severity of AP in COVID patients could partially contribute to this increment.
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