Evidence map›Paper›PMID 33259653›Full record

ReviewJournal of surgical oncology2021

The emerging role of immunotherapy for the treatment of sarcoma.

Nicholas D Klemen, Ciara M Kelly, Edmund K Bartlett

Abstract readReview
In one paragraph

Review in Journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Undifferentiated and Dedifferentiated Metastatic Melanomas Masquerading as Soft Tissue Sarcomas: Mutational Signature Analysis and Immunotherapy Response.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2023
    Article
  6. The Landscape of Immunotherapy for Retroperitoneal Sarcoma.Current oncology (Toronto, Ont.) · 2023
    Review
  7. Review
  8. Article
  9. Long-term Follow-up and Patterns of Response, Progression, and Hyperprogression in Patients after PD-1 Blockade in Advanced Sarcoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Case Report: Response to Regional MelphalanFrontiers in oncology · 2021
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nicholas D KlemenDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Ciara M KellyDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Edmund K BartlettDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0000-0002-0923-153X

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Targeting Oncogenic Pathways in Genetically Complex SarcomasP50CA217694 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Marc Ladanyi · 2018 to 2026
$21.5M
NCI NIH HHS P30 CA008748NCI NIH HHS P30-CA008748NCI NIH HHS P50 CA217694
6 · The paper itself

Abstract

Clinicians caring for patients with sarcoma founded the field of cancer immunotherapy. Despite this, contemporary success with immunotherapy for sarcoma has been limited. Here, we review immunotherapy for sarcoma including Coley's toxins, interleukin-2, adoptive cell transfer, and checkpoint blockade. We detail recent and ongoing efforts to combine checkpoint blockade with other immune modulators, surgery, or radiation. These results, along with ongoing investigations, have identified immunotherapeutic approaches as a promising avenue for progress in advanced sarcomas.

Indexed as

AnimalsClinical Trials, Phase I as TopicClinical Trials, Phase III as TopicHumansImmune Checkpoint InhibitorsImmunotherapyImmunotherapy, AdoptiveInterleukin-2Randomized Controlled Trials as TopicSarcomaImmune Checkpoint InhibitorsInterleukin-2bone sarcomacheckpoint inhibitionimmunotherapysarcomassoft-tissue sarcoma

Identifiers

PMID33259653
PMCPMC9212861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.