ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021
Iminoboronates as Dual-Purpose Linkers in Chemical Probe Development.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
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Who cites it
5 citing papers in PubMed.
- Progress and challenges in traceless ligand-directed labelling chemistry.Communications chemistry · 2026Review
- The linkage-type and the exchange molecule affect the protein-labeling efficiency of iminoboronate probes.Organic & biomolecular chemistry · 2023Article
- Protein-protein interactions: developing small-molecule inhibitors/stabilizers through covalent strategies.Trends in pharmacological sciences · 2023Review
- Iminoboronates as Dual-Purpose Linkers in Chemical Probe Development.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Modular Approaches to Synthesize Activity- and Affinity-Based Chemical Probes.Frontiers in chemistry · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Chemical probes that covalently modify proteins of interest are powerful tools for the research of biological processes. Important in the design of a probe is the choice of reactive group that forms the covalent bond, as it decides the success of a probe. However, choosing the right reactive group is not a simple feat and methodologies for expedient screening of different groups are needed. We herein report a modular approach that allows easy coupling of a reactive group to a ligand. α-Nucleophile ligands are combined with 2-formylphenylboronic acid derived reactive groups to form iminoboronate probes that selectively label their target proteins. A transimination reaction on the labeled proteins with an α-amino hydrazide provides further modification, for example to introduce a fluorophore.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.