Evidence map›Paper›PMID 33259329›Full record

ArticleThe Journal of rheumatology2021

Does the 1-year Decline in Walking Speed Predict Mortality Risk Beyond Current Walking Speed in Adults With Knee Osteoarthritis?

Hiral Master, Tuhina Neogi, Michael LaValley, Louise M Thoma, Yuqing Zhang, Dana Voinier, Meredith B Christiansen, Daniel K White

Open access · greenAbstract read
In one paragraph

Article in The Journal of rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Hiral MasterH. Master, PT, PhD, MPH, Department of Physical Therapy, College of Health Sciences, University of Delaware, Biomechanics and Movement Science Interdisciplinary Program, University of Delaware, and Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0003-0019-3087
Tuhina NeogiT. Neogi, MD, PhD, Department of Medicine, Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts.
Michael LaValleyM. LaValley, PhD, School of Public Health, Boston University, Boston, Massachusetts.
Louise M ThomaL.M. Thoma, PT, PhD, Division of Physical Therapy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-3077-0423
Yuqing ZhangY. Zhang, PhD, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Dana VoinierD. Voinier, PT, DPT, M.B. Christiansen, PT, PhD, D.K. White, PT, ScD, MSc, Department of Physical Therapy, College of Health Sciences, University of Delaware and Biomechanics and Movement Science Interdisciplinary Program, University of Delaware, Newark, Delaware, USA.ORCID 0000-0001-5141-5212
Meredith B ChristiansenD. Voinier, PT, DPT, M.B. Christiansen, PT, PhD, D.K. White, PT, ScD, MSc, Department of Physical Therapy, College of Health Sciences, University of Delaware and Biomechanics and Movement Science Interdisciplinary Program, University of Delaware, Newark, Delaware, USA.ORCID 0000-0002-3745-0772
Daniel K WhiteD. Voinier, PT, DPT, M.B. Christiansen, PT, PhD, D.K. White, PT, ScD, MSc, Department of Physical Therapy, College of Health Sciences, University of Delaware and Biomechanics and Movement Science Interdisciplinary Program, University of Delaware, Newark, Delaware, USA. dkw@udel.edu.ORCID 0000-0003-3792-4621
University of Delaware · USBoston University · USHarvard University · USUniversity of North Carolina at Chapel Hill · US

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
MULTICENTER CAREER DEVELOPMENT PROGRAM FOR PHYSICAL AND OCCUPATIONAL THERAPYK12HD055931 · NICHD · WASHINGTON UNIVERSITY · PI HAYES, MARCIE HARRIS · 2007 to 2021
$12.7M
Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2019 to 2026
$6.9M
PT/PHD Predoctoral Training Program Diversity SupplementT32HD007490 · NICHD · UNIVERSITY OF DELAWARE · PI DARCY S. REISMAN · 1996 to 2026
$3.7M
University of Massachusetts Center for Clinical and Translational ScienceTL1TR001454 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEWIS, BRIAN C · 2015 to 2024
$3.6M
Characterization of Rapidly Progressive Knee OsteoarthritisR01AR065977 · NIAMS · TUFTS MEDICAL CENTER · PI DRIBAN, JEFFREY B · 2015 to 2018
$1.5M
The Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and PainK24AR070892 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2017 to 2026
$1.1M
The Relation of Altered Pain Processing to Impact Loading and Response to a Gait Retraining Treatment in Knee OsteoarthritisK23AR070913 · NIAMS · UNIVERSITY OF DELAWARE · PI STEFANIK, JOSHUA JON · 2017 to 2021
$828k
A Novel Physical Therapy Administered Physical Activity Intervention After TKRR21AR071079 · NIAMS · UNIVERSITY OF DELAWARE · PI WHITE, DANIEL K · 2017 to 2019
$539k
Physical Activity, Weight Gain, and Risk for Knee Osteoarthritis after Traumatic Knee InjuryF32AR073090 · NIAMS · UNIVERSITY OF DELAWARE · PI THOMA, LOUISE M. · 2018 to 2019
$87k
NCATS NIH HHS TL1 TR001454NIAMS NIH HHS F32 AR073090NIAMS NIH HHS K23 AR070913NIAMS NIH HHS K24 AR070892NIAMS NIH HHS P30 AR072571NIAMS NIH HHS R01 AR065977NIAMS NIH HHS R21 AR071079NICHD NIH HHS K12 HD055931NICHD NIH HHS T32 HD007490NIGMS NIH HHS U54 GM104941
6 · The paper itself

Abstract

objectiveTo investigate whether walking speed at 1 timepoint, decline over the past 12 months, or both predict mortality risk over 11 years in adults with, or at risk of, knee osteoarthritis (OA).

methodsUsing the data from the Osteoarthritis Initiative, we defined slow versus adequate walking speed as walking < 1.22 versus ≥ 1.22 m/s on a 20m walk test during the 12-month follow-up visit. We defined meaningful decline (yes/no) as slowing ≥ 0.08 m/s over the past year. At the 12-month visit, we classified adequate sustainers as those with adequate walking speed and no meaningful decline, slow sustainers as slow walking speed and no meaningful decline, adequate decliners as adequate walking speed and meaningful decline, and slow decliners as slow walking speed and meaningful decline. Mortality was recorded over 11 years. To examine the association of walking speed with mortality, HR and 95% CI were calculated using Cox regression, adjusted for potential confounders.

resultsOf 4229 participants in the analytic sample (58% female, age 62 ± 9 yrs, BMI 29 ± 5 kg/m

conclusionIn adults with, or at risk of, knee OA, walking slower than 1.22 m/s in the present increased mortality risk, regardless of decline over the previous year.

Indexed as

Osteoarthritis, KneeAdultFemaleHumansMaleMiddle AgedRisk FactorsWalkingWalking Speeddeclineknee osteoarthritismortalitywalking speed

Identifiers

PMID33259329
PMCPMC7854382
OpenAlexW3082317921

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.