Evidence map›Paper›PMID 33259260›Full record

ArticleThe Journal of international medical research2020

Clinical treatment and medication in decreasing the development of major depression caused by spinal fracture.

Chih-Yu Chang, Wen-Liang Chen, Pei-You Hsieh, Shinn-Ying Ho, Cheng-Chieh Huang, Tsung-Han Lee, Chu-Chung Chou, Chin-Fu Chang, Yat-Yin Law, Yan-Ren Lin

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Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Chih-Yu ChangDepartment of Emergency Medicine, Everan Hospital, Taichung, Taiwan.
Wen-Liang ChenDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Pei-You HsiehDepartment of Emergency and Critical Care Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Shinn-Ying HoDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Cheng-Chieh HuangDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Tsung-Han LeeDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Chu-Chung ChouDepartment of Emergency and Critical Care Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Chin-Fu ChangDepartment of Emergency and Critical Care Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Yat-Yin LawSchool of Medicine, Chung Shan Medical University, Taichung, Taiwan.ORCID https://orcid.org/0000-0001-7610-8681
Yan-Ren LinDepartment of Emergency and Critical Care Medicine, Changhua Christian Hospital, Changhua, Taiwan.ORCID https://orcid.org/0000-0002-9015-2678
National Yang Ming Chiao Tung University · TWKaohsiung Medical University · TWChanghua Christian Hospital · TWChung Shan Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic pain and limited activities of daily living after spinal fracture may induce the occurrence of major depression (MD); however, risk factors regarding medications, surgical intervention, and severity of fracture are unclear. We aimed to analyze risk factors of MD development after spinal fracture.

methodsThis was a retrospective database study, using the health care database of the Taiwan government. We included 11,225 patients with new spinal fracture (study group), and 33,675 matched patients without fracture (comparison group). We respectively reviewed data of each participant for 3 years to assess the development of MD. The Cox proportional hazards model was used to determine the prevalence of MD, after adjusting for patient demographics, medications, surgical interventions, spinal cord involvement, and postfracture comorbidities.

resultsIn total, 187 fracture patients (1.7%) and 281 nonfracture patients (0.8%) developed new-onset MD (hazard ratio [HR]:1.96, (95% confidence interval [CI]: 1.63-2.36)). Spinal cord involvement (HR: 2.96, 95% CI: 2.54-3.42) and postfracture comorbidities (HR: 3.51, 95% CI: 2.86-3.97) obviously increased the risk of MD.

conclusionsPatients with spinal fracture (spinal cord involvement and postfracture comorbidities) were more likely to develop MD. Early surgical interventions (vertebroplasty) and medications (narcotics) may decrease the risk of MD.

Indexed as

Major Depressive DisorderSpinal FracturesActivities of Daily LivingDepressionHumansRetrospective StudiesRisk FactorsTaiwanactivities of daily livingchronic paindepressionnarcoticsSpinal fracturesurgical intervention

Identifiers

PMID33259260
PMCPMC7711237
OpenAlexW3107475549

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.