Evidence map›Paper›PMID 33259076›Full record

ArticleClinical transplantation2021

Long-term outcomes in kidney transplant recipients with end-stage kidney disease due to anti-glomerular basement membrane disease.

Tripti Singh, Talar B Kharadjian, Brad C Astor, Sarah E Panzer

Open access · greenAbstract read
In one paragraph

Article in Clinical transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Anti-glomerular basement membrane disease-treatment standard.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  2. Article
  3. Article
  4. Review
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  7. Epidemiology, Impact, and Management Strategies of Anti-Glomerular Basement Membrane Disease.International journal of nephrology and renovascular disease · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tripti SinghDepartment of Medicine, University of Wisconsin Hospital & Clinics Madison, Madison, WI, USA.ORCID 0000-0002-8855-3421
Talar B KharadjianDepartment of Medicine, University of Wisconsin Hospital & Clinics Madison, Madison, WI, USA.
Brad C AstorDepartment of Medicine, University of Wisconsin Hospital & Clinics Madison, Madison, WI, USA.
Sarah E PanzerDepartment of Medicine, University of Wisconsin Hospital & Clinics Madison, Madison, WI, USA.
UW Health University Hospital · USUniversity of Wisconsin–Madison · US

Funding

Improving long-term allograft survival in kidney transplantation by targeting B cell survival cytokinesK23DK122136 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI PANZER, SARAH E · 2019 to 2022
$663k
NIDDK NIH HHS K23 DK122136NIDDK NIH HHS L30 DK126100
6 · The paper itself

Abstract

Anti-glomerular basement membrane (GBM) disease causes rapidly progressive glomerulonephritis and end-stage kidney disease (ESKD). Studies of post-transplant outcomes in patients with ESKD due to anti-GBM disease in the United States are lacking. To better characterize outcomes of transplant recipients with a history of anti-GBM disease, we examined patient survival and graft survival among recipients with anti-GBM disease compared with IgA nephropathy at a single center in the United States. We analyzed patient survival, graft survival, disease recurrence, and malignancy rates for kidney transplant recipients with ESKD due to biopsy-proven anti-GBM disease who underwent kidney transplantation at our center between 1994 and 2015. 26 patients with biopsy-proven anti-GBM disease and 314 patients with IgAN underwent kidney transplantation from 1994 to 2015. The incidence of graft loss was 6.2 per 100 person-years for anti-GBM disease, which was similar to IgAN (4.08 per 100 person-years, p = .09). Patient mortality for anti-GBM was 0.03 per 100 person-years, similar to IgAN (0.02 per 100 person-years, p = .12). Disease recurrence occurred in one of the 26 anti-GBM patients. Four out of 26 patients (15%) developed malignancy, most commonly skin cancer. Long-term graft and patient survival for patients with ESKD due to anti-GBM was similar to IgAN after kidney transplantation.

Indexed as

Anti-Glomerular Basement Membrane DiseaseGlomerulonephritis, IGAKidney Failure, ChronicKidney TransplantationGraft SurvivalHumansKidneyNeoplasm Recurrence, LocalRecurrenceTransplant Recipientsanti-GBM diseasedisease recurrencekidney transplantlong-term patient and graft outcomespost-transplant malignancy

Identifiers

PMID33259076
PMCPMC8162922
OpenAlexW3109093154

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.