Evidence map›Paper›PMID 33259032›Full record

ArticleEJNMMI research2020

Inter- and intraobserver agreement of the quantitative assessment of [

Daniel Johnathan Hughes, Gitasha Chand, Vicky Goh, Gary J R Cook

Retracted 2 registry-linked trialsOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in EJNMMI research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to 2 registered trials, which are not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02978196 early_phase1completednot on this map

99mTc/68Ga Labeled Anti-PD-L1 sdAb in Assessment of Programmed Death Ligand-1 Expression in Non-small Cell Lung Cancer

TypeinterventionalSponsorShanghai General Hospital, Shanghai Jiao Tong University School of MedicineRan2018 to 2022Enrolled34ConditionsNon-Small Cell Lung CancerArmsInjection of 99mTc-NM-01, Injection of 68Ga-NM-01
NCT04992715 phase2unknown statusnot on this mapstarted 2022, after this paper: background citation

A Single-arm, Phase II Study to Evaluate PD-L1 Expression in Non-Small Cell Lung Cancer Using the 99mTc Labelled Anti-PD-L1 Single Domain Antibody (NM-01)

TypeinterventionalSponsorNanoMab Technology (UK) LimitedRan2022 to 2023Enrolled15ConditionsNon-Small Cell Lung CancerArms[99mTc]-NM01 SPECT/CT
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Pharmaceutics · 2023
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Daniel Johnathan HughesDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, 4th Floor, Lambeth Wing, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK.ORCID http://orcid.org/0000-0003-2641-7632
Gitasha ChandDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, 4th Floor, Lambeth Wing, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK.ORCID http://orcid.org/0000-0003-3565-3901
Vicky GohDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, 4th Floor, Lambeth Wing, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK.ORCID http://orcid.org/0000-0002-2321-8091
Gary J R CookDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, 4th Floor, Lambeth Wing, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK. gary.cook@kcl.ac.uk.ORCID http://orcid.org/0000-0002-8732-8134
St Thomas' Hospital · GB

Funding

Cancer Research UK 16463
6 · The paper itself

Abstract

purposeCheckpoint inhibition therapy using monoclonal antibodies against programmed cell death protein 1 (PD-1) or its ligand (PD-L1) is now standard management of non-small cell lung cancer (NSCLC). PD-L1 expression is a validated and approved prognostic and predictive biomarker for anti-PD-1/PD-L1 therapy. Technetium-99 m [

methods[

resultsIntraclass correlation of primary lung tumour-to-blood pool (T:BP; ICC 0.83, 95% CI 0.73-0.90) and lymph node metastasis-to-blood pool (LN:BP; ICC 0.87, 0.81-0.92) measures of [

conclusionGood to excellent inter- and intraobserver agreement of the quantitative assessment of [ CLINICAL

trial registrationClinicalTrials.gov identifier no. NCT02978196. Registered 30th November 2016.

Indexed as

ImmunotherapyNon-small cell lung cancerPD-L1Single-domain antibody (sdAb)SPECTTechnetium

Identifiers

PMID33259032
PMCPMC7708592
OpenAlexW3108476541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.