ArticleVirologica Sinica2021
Beta- and Novel Delta-Coronaviruses Are Identified from Wild Animals in the Qinghai-Tibetan Plateau, China.
Article in Virologica Sinica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Hidden diversity of coronaviruses in high-altitude plateau mammals.Virologica Sinica · 2026Article
- Epidemiological surveillance and genomic characterisation of betacoronavirus inOne health (Amsterdam, Netherlands) · 2026Article
- Characterization of viral diversity in wild marmot blood from the Qinghai-Tibet Plateau.Frontiers in microbiology · 2026Article
- RNA virome of ticks and fleas infesting Marmota himalayana from the Qinghai-Tibet plateau.Animal microbiome · 2025Article
- Coronaviruses in wild rodent and eulipotyphlan small mammals: a review of diversity, ecological implications and surveillance considerations.The Journal of general virology · 2025Review
- Five-year longitudinal surveillance reveals the continual circulation of both alpha- and beta-coronaviruses in Plateau and Gansu pikas (Emerging microbes & infections · 2024Article
- Genetic characterization of the first Deltacoronavirus from wild birds around Qinghai Lake.Frontiers in microbiology · 2024Article
- A novel bat coronavirus with a polybasic furin-like cleavage site.Virologica Sinica · 2023Article
- Mathematical Modeling of SARS-CoV-2 Omicron Wave under Vaccination Effects.Computation (Basel, Switzerland) · 2023Article
- Tracking the first SARS-CoV-2 Omicron BA.5.1.3 outbreak in China.Frontiers in microbiology · 2023Article
- Species-level microbiota of ticks and fleas fromFrontiers in microbiology · 2023Article
- Metagenomic analysis of viromes in tissues of wild Qinghai vole from the eastern Tibetan Plateau.Scientific reports · 2022Article
- No Evidence for the Presence of SARS-CoV-2 in Bank Voles and Other Rodents in Germany, 2020-2022.Pathogens (Basel, Switzerland) · 2022Article
- Novel pegiviruses infecting wild birds and rodents.Virologica Sinica · 2022Article
- Isolation and characterization of tick-borne Roseomonas haemaphysalidis sp. nov. and rodent-borne Roseomonas marmotae sp. nov.Journal of microbiology (Seoul, Korea) · 2022Article
- Article
- Identification of coronaviruses in farmed wild animals reveals their evolutionary origins in Guangdong, southern China.Virus evolution · 2022Article
- RNA Virus Diversity in Birds and Small Mammals From Qinghai-Tibet Plateau of China.Frontiers in microbiology · 2022Article
- Modular Evolution of Coronavirus Genomes.Viruses · 2021Article
- Analysis of Key Factors of a SARS-CoV-2 Vaccination Program: A Mathematical Modeling Approach.Epidemiologia (Basel, Switzerland) · 2021Article
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Outbreaks of severe virus infections with the potential to cause global pandemics are increasingly concerning. One type of those commonly emerging and re-emerging pathogens are coronaviruses (SARS-CoV, MERS-CoV and SARS-CoV-2). Wild animals are hosts of different coronaviruses with the potential risk of cross-species transmission. However, little is known about the reservoir and host of coronaviruses in wild animals in Qinghai Province, where has the greatest biodiversity among the world's high-altitude regions. Here, from the next-generation sequencing data, we obtained a known beta-coronavirus (beta-CoV) genome and a novel delta-coronavirus (delta-CoV) genome from faecal samples of 29 marmots, 50 rats and 25 birds in Yushu Tibetan Autonomous Prefecture, Qinghai Province, China in July 2019. According to the phylogenetic analysis, the beta-CoV shared high nucleotide identity with Coronavirus HKU24. Although the novel delta-CoV (MtCoV) was closely related to Sparrow deltacoronavirus ISU42824, the protein spike of the novel delta-CoV showed highest amino acid identity to Sparrow coronavirus HKU17 (73.1%). Interestingly, our results identified a novel host (Montifringilla taczanowskii) for the novel delta-CoV and the potential cross-species transmission. The most recent common ancestor (tMRCA) of MtCoVs along with other closest members of the species of Coronavirus HKU15 was estimated to be 289 years ago. Thus, this study increases our understanding of the genetic diversity of beta-CoVs and delta-CoVs, and also provides a new perspective of the coronavirus hosts.
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