ArticleMolecular biology and evolution2021
A Two-Locus System with Strong Epistasis Underlies Rapid Parasite-Mediated Evolution of Host Resistance.
Article in Molecular biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- Aphid herbivory on macrophytes drives adaptive evolution in an aquatic community via indirect effects.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Conceptual Disease Cycle Model to Link the Size of Past and Future Epidemics.Ecology and evolution · 2025Review
- Genetic basis of resistance in hosts facing alternative infection strategies by a virulent bacterial pathogen.G3 (Bethesda, Md.) · 2025Article
- Beyond genes-for-behaviour: The potential for genomics to resolve long-standing questions in avian brood parasitism.Ecology and evolution · 2024Review
- The Evolution of Extreme Genetic Variability in a Parasite-Resistance Complex.Genome biology and evolution · 2024Article
- Long-term balancing selection for pathogen resistance maintains trans-species polymorphisms in a planktonic crustacean.Nature communications · 2024Article
- Article
- Parasitoid Serpins Evolve Novel Functions to Manipulate Host Homeostasis.Molecular biology and evolution · 2023Article
- Uncovering the Genomic Basis of Infection Through Co-genomic Sequencing of Hosts and Parasites.Molecular biology and evolution · 2023Article
- QTL study reveals candidate genes underlying host resistance in a Red Queen model system.PLoS genetics · 2023Article
- Genetic Drift Shapes the Evolution of a Highly Dynamic Metapopulation.Molecular biology and evolution · 2022Article
- Genetic slippage after sex maintains diversity for parasite resistance in a natural host population.Science advances · 2022Article
- Review
- Population-Genomic Analysis Identifies a Low Rate of Global Adaptive Fixation in the Proteins of the Cyclical Parthenogen Daphnia magna.Molecular biology and evolution · 2022Article
- Balancing Selection for Pathogen Resistance Reveals an Intercontinental Signature of Red Queen Coevolution.Molecular biology and evolution · 2021Article
- Infection phenotypes of a coevolving parasite are highly diverse, structured, and specific.Evolution; international journal of organic evolution · 2021Article
- Long-read sequencing reveals the evolutionary drivers of intra-host diversity across natural RNA mycovirus infections.Virus evolution · 2021Article
- Genome-Wide Association Analysis Identifies a Genetic Basis of Infectivity in a Model Bacterial Pathogen.Molecular biology and evolution · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parasites are a major evolutionary force, driving adaptive responses in host populations. Although the link between phenotypic response to parasite-mediated natural selection and the underlying genetic architecture often remains obscure, this link is crucial for understanding the evolution of resistance and predicting associated allele frequency changes in the population. To close this gap, we monitored the response to selection during epidemics of a virulent bacterial pathogen, Pasteuria ramosa, in a natural host population of Daphnia magna. Across two epidemics, we observed a strong increase in the proportion of resistant phenotypes as the epidemics progressed. Field and laboratory experiments confirmed that this increase in resistance was caused by selection from the local parasite. Using a genome-wide association study, we built a genetic model in which two genomic regions with dominance and epistasis control resistance polymorphism in the host. We verified this model by selfing host genotypes with different resistance phenotypes and scoring their F1 for segregation of resistance and associated genetic markers. Such epistatic effects with strong fitness consequences in host-parasite coevolution are believed to be crucial in the Red Queen model for the evolution of genetic recombination.
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