Evidence map›Paper›PMID 33258944›Full record

ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2020

Clinical, haematological and biochemical profiling of podoconiosis lymphoedema patients prior to their involvement in a clinical trial in the Northwest Region of Cameroon.

Bertrand Lontum Ndzeshang, Randy Tchachoua Mbiakop, Gordon Takop Nchanji, Chi Anizette Kien, Glory Ngongeh Amambo, Raphael Awah Abong, Timothy Yuyun, Amuam Andrew Beng, John Bonekeh, Manuel Ritter and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 4 countries.

Bertrand Lontum NdzeshangDepartment of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.
Randy Tchachoua MbiakopDepartment of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.
Gordon Takop NchanjiDepartment of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.
Chi Anizette KienDepartment of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.
Glory Ngongeh AmamboDepartment of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.
Raphael Awah AbongDepartment of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.
Timothy YuyunRegional Hospital Bamenda, P.O. Box 818, Bamenda Cameroon.
Amuam Andrew BengDepartment of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.
John BonekehResearch Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon.
Manuel RitterInstitute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), Bonn, Germany.
Mathias Eyong EsumDepartment of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.
Jerome Fru ChoDepartment of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.
Abdel Jelil NjouendouDepartment of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.
Ignatius Nde NdiforNdop District Hospital, P.O. Box 07, Ndop, Cameroon.
Kebede DeribeGlobal Health and Infection Department, Brighton and Sussex Medical School, Brighton, BN1 9PX, UK.
Fanny Fri FombadDepartment of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.
Peter EnyongDepartment of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.
Ute Klarmann-SchulzInstitute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), Bonn, Germany.
Achim HoeraufInstitute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), Bonn, Germany.
Samuel WanjiDepartment of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.
University of Buea · CMGerman Center for Infection Research · DEBrighton and Sussex Medical School · GBUniversity Hospital Bonn · DE

Funding

Wellcome Trust 201900/Z/16/Z
6 · The paper itself

Abstract

backgroundPrior to carrying out clinical trials, it is important to assess the health status of the study participants to be able to interpret subsequent changes that may be related to the effects of the treatments during the follow-up of patients. This study presents the clinical, haematological and biochemical profiles of podoconiosis patients prior to their involvement in the PodoLEDoxy clinical trial.

methodsAll lower limb lymphoedema patients visiting the centre were screened and a podoconiosis diagnosis was based on clinical manifestation and detailed medical history. Patients who satisfied the eligibility criteria were enrolled in the study and their demographic data, vital signs and medical history were collected followed by biochemical and haematological examinations.

resultsOf the 222 participants enrolled in the study, 55.4% and 41.4% had either stage 3 or 2 podoconiosis as their highest stages, respectively. On physical examination, gastritis (46%) and poor vision (2.7%) were the most prevalent health issues identified. The majority of haematological and biochemical values were within the normal range except for mean platelet volume (47.7%), plateletcrit (58.1%), platelet distribution width (66.2%), mean corpuscular volume (67.6%) and red cell distribution width-standard deviation (79.3%), where >40% of the study participants had values out of the normal.

conclusionThe clinical, haematological and biochemical profiles of the study participants were largely within the normal range except for certain haematological parameters that might be worth investigating.

Indexed as

ElephantiasisLymphedemaCameroonErythrocyte IndicesHumansbiochemicalclinicalhaematologicallymphodemapodoconiosisprofiling

Identifiers

PMID33258944
PMCPMC7738657
OpenAlexW3108960160

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.