Evidence map›Paper›PMID 33258938›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Typhoid and Paratyphoid Cost of Illness in Nepal: Patient and Health Facility Costs From the Surveillance for Enteric Fever in Asia Project II.

Nelly Mejia, Taiwo Abimbola, Jason R Andrews, Krista Vaidya, Dipesh Tamrakar, Sailesh Pradhan, Rajani Shakya, Denise O Garrett, Kashmira Date, Sarah W Pallas

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Typhoid fever.Nature reviews. Disease primers · 2023
    Review
  7. Article
  8. Article
  9. Cost of Illness Due to Severe Enteric Fever in India.The Journal of infectious diseases · 2021
    Article
  10. Typhoid and Paratyphoid Cost of Illness in Pakistan: Patient and Health Facility Costs From the Surveillance for Enteric Fever in Asia Project II.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  11. Introducing Typhoid Conjugate Vaccine in South Asia: Lessons From the Surveillance for Enteric Fever in Asia Project.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  12. Typhoid and Paratyphoid Cost of Illness in Bangladesh: Patient and Health Facility Costs From the Surveillance for Enteric Fever in Asia Project II.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nelly MejiaGlobal Immunization Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Taiwo AbimbolaGlobal Immunization Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jason R AndrewsStanford University, Palo Alto, California, USA.
Krista VaidyaDhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Nepal.
Dipesh TamrakarDhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Nepal.
Sailesh PradhanKathmandu Medical College and Teaching Hospital, Kathmandu, Nepal.
Rajani ShakyaDhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Nepal.
Denise O GarrettApplied Epidemiology, Sabin Vaccine Institute, Washington, DC, USA.
Kashmira DateGlobal Immunization Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Sarah W PallasGlobal Immunization Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnteric fever is endemic in Nepal and its economic burden is unknown. The objective of this study was to estimate the cost of illness due to enteric fever (typhoid and paratyphoid) at selected sites in Nepal.

methodsWe implemented a study at 2 hospitals in Nepal to estimate the cost per case of enteric fever from the perspectives of patients, caregivers, and healthcare providers. We collected direct medical, nonmedical, and indirect costs per blood culture-confirmed case incurred by patients and their caregivers from illness onset until after enrollment and 6 weeks later. We estimated healthcare provider direct medical economic costs based on quantities and prices of resources used to diagnose and treat enteric fever, and procedure frequencies received at these facilities by enrolled patients. We collected costs in Nepalese rupees and converted them into 2018 US dollars.

resultsWe collected patient and caregiver cost of illness information for 395 patients, with a median cost of illness per case of $59.99 (IQR, $24.04-$151.23). Median direct medical and nonmedical costs per case represented ~3.5% of annual individual labor income. From the healthcare provider perspective, the average direct medical economic cost per case was $79.80 (range, $71.54 [hospital B], $93.43 [hospital A]).

conclusionsEnteric fever can impose a considerable economic burden on patients, caregivers, and health facilities in Nepal. These new estimates of enteric fever cost of illness can improve evaluation and modeling of the costs and benefits of enteric fever-prevention measures.

Indexed as

Paratyphoid FeverTyphoid FeverAsiaCost of IllnessHealth FacilitiesHumansNepalcost of illnessenteric feverNepalparatyphoidtyphoid

Identifiers

PMID33258938
PMCPMC7750979

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.