ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Illness Severity and Outcomes Among Enteric Fever Cases From Bangladesh, Nepal, and Pakistan: Data From the Surveillance for Enteric Fever in Asia Project, 2016-2019.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
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- Cost-effectiveness and public health impact of typhoid conjugate vaccine introduction strategies in Bangladesh.Vaccine · 2024Article
- Clinical presentation and outcome of enteric fever in adult patients with cancer: a perspective from Pakistan.Access microbiology · 2024Article
- Comparative study on epidemiological and etiological characteristics of patients with acute diarrhea with febrile or non-febrile symptoms in China.Infectious diseases of poverty · 2023Article
- Socioeconomic and ethnic inequalities in incidence and severity of enteric fever in England 2015-2019: analysis of a national enhanced surveillance system.Epidemiology and infection · 2023Article
- Clinical spectrum and outcomes of patients with different resistance patterns ofPakistan journal of medical sciences · 2022Article
- Introducing Typhoid Conjugate Vaccine in South Asia: Lessons From the Surveillance for Enteric Fever in Asia Project.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Utilization of Blood Culture in South Asia for the Diagnosis and Treatment of Febrile Illness.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Healthcare Utilization Patterns for Acute Febrile Illness in Bangladesh, Nepal, and Pakistan: Results from the Surveillance for Enteric Fever in Asia Project.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Spatial Heterogeneity of Enteric Fever in 2 Diverse Communities in Nepal.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
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10 authors at 7 institutions in 4 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEnteric fever can lead to prolonged hospital stays, clinical complications, and death. The Surveillance for Enteric Fever in Asia Project (SEAP), a prospective surveillance study, characterized the burden of enteric fever, including illness severity, in selected settings in Bangladesh, Nepal, and Pakistan. We assessed disease severity, including hospitalization, clinical complications, and death among SEAP participants.
methodsWe analyzed clinical and laboratory data from blood culture-confirmed enteric fever cases enrolled in SEAP hospitals and associated network laboratories from September 2016 to September 2019. We used hospitalization and duration of hospital stay as proxies for severity. We conducted a follow-up interview 6 weeks after enrollment to ascertain final outcomes.
resultsOf the 8705 blood culture-confirmed enteric fever cases enrolled, we identified 6 deaths (case-fatality ratio, .07%; 95% CI, .01-.13%), 2 from Nepal, 4 from Pakistan, and none from Bangladesh. Overall, 1.7% (90/5205) of patients recruited from SEAP hospitals experienced a clinical complication (Bangladesh, 0.6% [18/3032]; Nepal, 2.3% [12/531]; Pakistan, 3.7% [60/1642]). The most identified complications were hepatitis (n = 36), septic shock (n = 22), and pulmonary complications/pneumonia (n = 13). Across countries, 32% (2804/8669) of patients with hospitalization data available were hospitalized (Bangladesh, 27% [1295/4868]; Nepal, 29% [455/1595]; Pakistan, 48% [1054/2206]), with a median hospital stay of 5 days (IQR, 3-7).
conclusionsWhile defined clinical complications and deaths were uncommon at the SEAP sites, the high proportion of hospitalizations and prolonged hospital stays highlight illness severity and the need for enteric fever control measures, including the use of typhoid conjugate vaccines.
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