ArticleCerebral cortex (New York, N.Y. : 1991)2021
Temporal Dynamics of Functional Brain States Underlie Cognitive Performance.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Methylphenidate differentially alters corticostriatal connectivity after traumatic brain injury.Brain : a journal of neurology · 2025Trial
- Effects of light on brain-state dynamics and energy landscape.Network neuroscience (Cambridge, Mass.) · 2026Article
- Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation.Alzheimer's research & therapy · 2025Article
- The Effect of Modular Degeneracy on Neuroimaging Data.Brain connectivity · 2025Article
- Adolescent-to-adult gains in cognitive flexibility are adaptively supported by reward sensitivity, exploration, and neural variability.Current opinion in behavioral sciences · 2024Article
- Temporal and spatial variability of dynamic microstate brain network in disorders of consciousness.CNS neuroscience & therapeutics · 2024Article
- Effect of the VR-guided grasping task on the brain functional network.Biomedical optics express · 2024Article
- Disrupted Dynamic Interactions Between Large-Scale Brain Networks in Cocaine Users Are Associated With Dependence Severity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Cilia in the Striatum Mediate Timing-Dependent Functions.Molecular neurobiology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
The functional organization of the human brain adapts dynamically in response to a rapidly changing environment. However, the relation of these rapid changes in functional organization to cognitive functioning is not well understood. This study used a graph-based time-frame modularity analysis approach to identify temporally recurrent functional configuration patterns in neural responses to an n-back working memory task during fMRI. Working memory load was manipulated to investigate the functional relevance of the identified brain states. Four distinct brain states were defined by the predominant patterns of activation in the task-positive, default-mode, sensorimotor, and visual networks. Associated with escalating working memory load, the occurrence of the task-positive state and the probability of transitioning into this state increased. In contrast, the occurrence of the default-mode and sensorimotor states and the probability of these 2 states transitioning away from the task-positive state decreased. The task-positive state occurrence rate and the probability of transitioning from the default-mode state back to the task-positive state explained a significant and unique portion of the variance in task performance. The results demonstrate that dynamic brain activities support successful cognitive functioning and may have heuristic value for understanding abnormal cognitive functioning associated with multiple neuropsychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.