Evidence map›Paper›PMID 33258733›Full record

SynthesisPathogens and global health2021

Systematic review and meta-analytic findings on the association between killer-cell immunoglobulin-like receptor genes and susceptibility to pulmonary tuberculosis.

Melodi Omraninava, Sahar Mehranfar, Arezou Khosrojerdi, Sirous Jamalzehi, Jafar Karami, Morteza Motallebnezhad, Mohammad Reza Javan, Saeed Aslani, Hamed Mohammadi, Ahmad Kousha

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pathogens and global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. The Role of Killer Ig-like Receptors in Diseases from A to Z.International journal of molecular sciences · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 1 country.

Melodi OmraninavaDepartment of Infectious Disease, Faculty of Medical Sciences, Sari Branch, Islamic Azad University , Sari, Iran.
Sahar MehranfarDepartment of Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences , Urmia, Iran.
Arezou KhosrojerdiDepartment of Immunology, Faculty of Medical Sciences, Tarbiat Modares University , Tehran, Iran.
Sirous JamalzehiDepartment of Medical Laboratory Sciences, Iranshahr University of Medical Sciences , Iranshahr, Iran.
Jafar KaramiDepartment of Immunology, School of Medicine, Iran University of Medical Sciences , Tehran, Iran.
Morteza MotallebnezhadDepartment of Immunology, School of Medicine, Iran University of Medical Sciences , Tehran, Iran.
Mohammad Reza JavanDepartment of Immunology, Faculty of Medicine, Zabol University of Medical Sciences , Zabol, Iran.
Saeed AslaniDepartment of Immunology, School of Medicine, Tehran University of Medical Sciences , Tehran, Iran.
Hamed MohammadiDepartment of Immunology, School of Medicine, Alborz University of Medical Sciences , Alborz, Iran.
Ahmad KoushaDepartment of Health Education and Health Promotion, Faculty of Health, Tabriz University of Medical Sciences , Tabriz, Iran.
Iran University of Medical Sciences · IRIranshahr University · IRIslamic Azad University Sari Branch · IRJahrom University of Medical Sciences · IRTabriz University of Medical Sciences · IRTarbiat Modares University · IRTehran University of Medical Sciences · IRUrmia University of Medical SciencesZabol University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies have evaluated the association between killer-cell immunoglobulin-like receptors (KIR) genes and susceptibility risk to tuberculosis (TB) infection. Nonetheless, their outcomes have not been conclusive and consistent. Here we implemented a systematic review and meta-analysis of KIR genes association to susceptibility risk of pulmonary TB (PTB) infection to attain a clear understanding of the involvement of these genes in susceptibility to PTB infection. A systematic search was conducted in the MEDLINE/PubMed and Scopus databases to find case-control studies published before November 2020. Pooled odds ratio (OR) and 95% confidence interval (95% CI) were calculated to determine the association between KIR genes and risk of PTB infection. After comprehensive searching and implementing the inclusion and exclusion criteria, 10 case-control studies were included in the meta-analysis. Four KIR genes were found to have significant positive association with PTB susceptibility risk of infection, including

Indexed as

Receptors, KIRTuberculosis, PulmonaryGenetic Predisposition to DiseaseGenotypeHumansReceptors, KIRGene associationInfectious diseaseKiller-cell immunoglobulin-like receptorsMeta-analysisMycobacterium tuberculosisNatural killer cellPulmonary tuberculosisSystematic review

Identifiers

PMID33258733
PMCPMC7850413
OpenAlexW3109498642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.