Evidence map›Paper›PMID 33258708›Full record

ArticleEpigenetics2021

DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the

A M Raizis, H M Racher, A Foucal, H Dimaras, B L Gallie, P M George

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Correlation between FamilyDisease markers · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

A M RaizisC/o Dept. of Molecular Pathology, Canterbury Health Laboratories, Christchurch, New Zealand.
H M RacherDepartment of Genetics, c/o Impact Genetics, Bowmanville, Ontario, Canada.
A FoucalUniversité de Nantes, INSERM, l'institut du thorax, F-44000 Nantes, France.
H DimarasDepartments of Ophthalmology & Vision Sciences, The Hospital for Sick Children, Toronto, Canada.ORCID 0000-0003-1164-2001
B L GallieDepartments of Ophthalmology & Vision Sciences, The Hospital for Sick Children, Toronto, Canada.
P M GeorgeDepartment of Pathology, University of Otago, Christchurch, New Zealand.
University of Toronto · CACanterbury Health Laboratories · NZImpact · CAInserm · FRUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA hypermethylation events occur frequently in human cancers, but less is known of the mechanisms leading to their initiation. Retinoblastoma, an intraocular cancer affecting young children, involves bi-allelic inactivation of the

Indexed as

Retinal NeoplasmsRetinoblastomaChild, PreschoolDNA MethylationEpigenesis, GeneticGenes, RetinoblastomaHumansRetinoblastoma Binding ProteinsUbiquitin-Protein LigasesRB1 protein, humanRetinoblastoma Binding ProteinsUbiquitin-Protein LigasescancerCTCFDNA hypermethylationEpimutationsloop extrusionpromoterRB1retinoblastoma

Identifiers

PMID33258708
PMCPMC8451468
OpenAlexW3108451575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.