Evidence map›Paper›PMID 33258596›Full record

ArticleEnvironmental science & technology2020

Contribution of Time, Taxonomy, and Selective Antimicrobials to Antibiotic and Multidrug Resistance in Wastewater Bacteria.

Hannah K Gray, Keith K Arora-Williams, Charles Young, Edward Bouwer, Meghan F Davis, Sarah P Preheim

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hannah K GrayDepartment of Environmental Health and Engineering, Whiting School of Engineering, Johns Hopkins University, 3400 North Charles Street, 313 Ames Hall, Baltimore, Maryland 21218, United States.
Keith K Arora-WilliamsDepartment of Environmental Health and Engineering, Whiting School of Engineering, Johns Hopkins University, 3400 North Charles Street, 313 Ames Hall, Baltimore, Maryland 21218, United States.
Charles YoungThe Johns Hopkins Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, Maryland 20723, United States.
Edward BouwerDepartment of Environmental Health and Engineering, Whiting School of Engineering, Johns Hopkins University, 3400 North Charles Street, 313 Ames Hall, Baltimore, Maryland 21218, United States.
Meghan F DavisDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, E7612, Baltimore, Maryland 21205, United States.
Sarah P PreheimDepartment of Environmental Health and Engineering, Whiting School of Engineering, Johns Hopkins University, 3400 North Charles Street, 313 Ames Hall, Baltimore, Maryland 21218, United States.ORCID 0000-0001-7365-2382
Johns Hopkins University · USJohns Hopkins University Applied Physics Laboratory · US

Funding

Effects of pest and pet animal microbiota on child microbiota and asthma: a one health studyK01OD019918 · OD · JOHNS HOPKINS UNIVERSITY · PI DAVIS, MEGHAN F. · 2016 to 2020
$621k
NIH HHS K01 OD019918
6 · The paper itself

Abstract

The use of nontherapeutic broad-spectrum antimicrobial agents triclosan (TCS) and benzalkonium chloride (BC) can contribute to bacterial resistance to clinically relevant antibiotics. Antimicrobial-resistant bacteria within wastewater may reflect the resistance burden within the human microbiome, as antibiotics and pathogens in wastewater can track with clinically relevant parameters during perturbations to the community. In this study, we monitored culturable and resistant wastewater bacteria and cross-resistance to clinically relevant antibiotics to gauge the impact of each antimicrobial and identify factors influencing cross-resistance profiles. Bacteria resistant to TCS and BC were isolated from wastewater influent over 21 months, and cross-resistance, taxonomy, and monthly changes were characterized under both antimicrobial selection regimes. Cross-resistance profiles from each antimicrobial differed within and between taxa. BC-isolated bacteria had a significantly higher prevalence of resistance to "last-resort antibiotic" colistin, while isolates resistant to TCS exhibited higher rates of multidrug resistance. Prevalence of culturable TCS-resistant bacteria decreased over time following Food and Drug Administration (FDA) TCS bans. Cross-resistance patterns varied according to sampling date, including among the most clinically important antibiotics. Correlations between strain-specific resistance profiles were largely influenced by taxonomy, with some variations associated with sampling date. The results reveal that time, taxonomy, and selection by TCS and BC impact features of cross-resistance patterns among diverse wastewater microorganisms, which could reflect the variety of factors influencing resistance patterns relevant to a community microbiome.

Indexed as

Anti-Infective AgentsWastewaterAnti-Bacterial AgentsBacteriaDrug Resistance, BacterialDrug Resistance, MultipleHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAnti-Infective AgentsWastewater

Identifiers

PMID33258596
PMCPMC8463082
OpenAlexW3108663189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.