Evidence map›Paper›PMID 33258511›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2021

Dentate Nucleus Neuronal Density: A Postmortem Study of Essential Tremor Versus Control Brains.

Whitney G Hartstone, Mark H Brown, Geoffrey C Kelly, William J Tate, Sheng-Han Kuo, Andrew J Dwork, Elan D Louis, Phyllis L Faust

Open access · greenAbstract read
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Essential tremor: Clinical perspectives and pathophysiology.Journal of the neurological sciences · 2022
    Review
  8. Essential Tremor: Five New Things.Neurology. Clinical practice · 2022
    Article
  9. Article
  10. Article
  11. Essential tremor.Nature reviews. Disease primers · 2021
    Review
  12. Structural Correlates of the Sensorimotor Cerebellum in Parkinson's Disease and Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Whitney G HartstoneDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital, New York, New York, USA.
Mark H BrownDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital, New York, New York, USA.
Geoffrey C KellyDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital, New York, New York, USA.
William J TateDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital, New York, New York, USA.
Sheng-Han KuoDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Andrew J DworkDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital, New York, New York, USA.
Elan D LouisDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern, Dallas, Texas, USA.
Phyllis L FaustDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital, New York, New York, USA.ORCID 0000-0001-6533-7921
NewYork–Presbyterian Hospital · USColumbia University · USThe University of Texas Southwestern Medical Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Clinical Pathological Study of Cognitive Impairment in Essential TremorR01NS086736 · NINDS · YALE UNIVERSITY · PI COSENTINO, STEPHANIE ANN, LOUIS, ELAN D · 2014 to 2023
$8.1M
Identification of Susceptibility Genes for Essential TremorR01NS073872 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLARK, LORRAINE N, LOUIS, ELAN D · 2011 to 2019
$7.4M
Environmental Epidemiology of Essential TremorR01NS094607 · NINDS · YALE UNIVERSITY · PI LOUIS, ELAN D · 2016 to 2020
$3.9M
PATHOLOG-OMICS - ESSENTIAL TREMOR IN THE BROADER CONTEXT OF NEURODEGENERATIONR01NS088257 · NINDS · YALE UNIVERSITY · PI FAUST, PHYLLIS L, LOUIS, ELAN D · 2015 to 2019
$3.3M
in Vivo Quantification of Cerebellar GABA and NAA in Essential TremorR01NS085136 · NINDS · YALE UNIVERSITY · PI MATUSKEY, DAVID A · 2013 to 2017
$3.3M
Accelerated non-atherosclerotic brain arterial aging relationship to Alzheimer's diseaseR01AG066162 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUTIERREZ, JOSE · 2019 to 2023
$3.1M
Targeting Cerebellar Excitatory Synapses for Tremor ProgressionR01NS118179 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2020 to 2024
$2.2M
Cerebellar Circuitry in the Pathophysiology of TremorR01NS104423 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2018 to 2022
$2.0M
Application of Advanced Quantitative Methods to Schizophrenia Research in MacedoniaR56MH117769 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DWORK, ANDREW J, KOCAREV, LJUPCHO · 2019 to 2019
$491k
Dietary Contribution in Cerebellar AtaxiaR03NS114871 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2019 to 2020
$162k
Neuronal Subtype Specific Epigenetic Regulation in SchizophreniaI01BX002876 · VA · JAMES J PETERS VA MEDICAL CENTER · PI DRACHEVA, STELLA · 2016 to 2020
–
BLRD VA I01 BX002876BLRD VA I01 BX003794NCATS NIH HHS UL1 TR001863NIA NIH HHS R01 AG066162NIMH NIH HHS R56 MH117769NINDS NIH HHS R01 NS073872NINDS NIH HHS R01 NS085136NINDS NIH HHS R01 NS086736NINDS NIH HHS R01 NS088257NINDS NIH HHS R01 NS094607NINDS NIH HHS R01 NS104423NINDS NIH HHS R01 NS118179NINDS NIH HHS R03 NS114871
6 · The paper itself

Abstract

backgroundEssential tremor involves the cerebellum, yet quantitative analysis of dentate nucleus neurons has not been conducted.

objectivesTo quantitatively compare neuronal density or neuronal number in the dentate nucleus of essential tremor versus age-matched controls.

methodsUsing a 7-μm thick Luxol fast blue hematoxylin and eosin-stained paraffin section, dentate nucleus neuronal density (neurons/mm

resultsDentate nucleus neuronal density did not differ between essential tremor cases and controls (P = 0.44). Total dentate nucleus neuronal number correlated with neuronal density (P = 0.007) and did not differ between essential tremor cases and controls (P = 0.95).

conclusionsNeuronal loss, observed in the Purkinje cell population in essential tremor, did not seem to similarly involve the dentate nucleus in essential tremor. © 2020 International Parkinson and Movement Disorder Society.

Indexed as

Essential TremorCerebellar NucleiCerebellumHumansNeuronsPurkinje Cellsessential tremor; cerebellum; dentate neuron; stereology; pathology

Identifiers

PMID33258511
PMCPMC8046734
OpenAlexW3108372159

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.