Evidence map›Paper›PMID 33258452›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2021

Potential role of exosome-based allorecognition pathways involved in lung transplant rejection.

Billanna Hwang, James Bryers, Michael S Mulligan

Abstract read
In one paragraph

Article in The Journal of thoracic and cardiovascular surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Mesenchymal stromal cell extracellular vesicles reduceAmerican journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  2. Let-7b-5p loaded Mesenchymal Stromal Cell Extracellular Vesicles reducebioRxiv : the preprint server for biology · 2025
    Article
  3. Review
  4. Review
  5. Extracellular Vesicles in Transplantation.Frontiers in immunology · 2022
    Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Billanna HwangDepartment of Surgery, University of Washington School of Medicine, Seattle, Wash; Center for Lung Biology, University of Washington, Seattle, Wash; West Coast Exosortium (WestCo Exosortium), Seattle, Wash. Electronic address: bhwang@uw.edu.
James BryersCenter for Lung Biology, University of Washington, Seattle, Wash; West Coast Exosortium (WestCo Exosortium), Seattle, Wash; Department of Bioengineering, University of Washington, Seattle, Wash.
Michael S MulliganDepartment of Surgery, University of Washington School of Medicine, Seattle, Wash; Center for Lung Biology, University of Washington, Seattle, Wash; West Coast Exosortium (WestCo Exosortium), Seattle, Wash; Department of Medicine, University of Washington School of Medicine, Seattle, Wash.

Funding

Periodontal Biomaterials with BITE (Biofilm Immunity with Tissue Engineering)R01DE018701 · NIDCR · UNIVERSITY OF WASHINGTON · PI BRYERS, JAMES D. · 2008 to 2019
$5.0M
Role of TLR-4 in Lung Reperfusion InjuryR01HL093097 · NHLBI · UNIVERSITY OF WASHINGTON · PI MULLIGAN, MICHAEL SCOTT · 2009 to 2013
$1.9M
Tissue Regeneration by Engineered Extracellular VesiclesR01GM128991 · NIGMS · UNIVERSITY OF WASHINGTON · PI BRYERS, JAMES D. · 2019 to 2022
$1.9M
NHLBI NIH HHS R01 HL093097NIDCR NIH HHS R01 DE018701NIGMS NIH HHS R01 GM128991
6 · The paper itself

Abstract

Innate and adaptive immunity both contribute to allorecognition mechanisms that drive rejection after lung transplantation. Classic allorecognition pathways have been extensively described, but there continues to be several unanswered questions. Exosome research appears to be a novel and potentially significant area of allorecognition research and could be the missing link that answers some existing questions. This article reviews literature that is associated with allorecognition pathways and the role of exosomes in alloreactivity.

Indexed as

Adaptive ImmunityAnimalsAntigen-Presenting CellsExosomesGraft RejectionHumansImmunity, InnateLungLung Transplantation

Identifiers

PMID33258452
PMCPMC7909740

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.