Evidence map›Paper›PMID 33258448›Full record

ArticleeLife2020

Glutamine metabolism modulates azole susceptibility in

Peter C Dumoulin, Joshua Vollrath, Sheena Shah Tomko, Jennifer X Wang, Barbara Burleigh

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Albaconazole Polymeric Nanocapsules for TreatingPathogens (Basel, Switzerland) · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Chemical Cartography Approaches to Study Trypanosomatid Infection.Journal of visualized experiments : JoVE · 2022
    Article
  12. Endogenous Sterol Synthesis Is Dispensable forFrontiers in microbiology · 2022
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review on Experimental Treatment Strategies AgainstJournal of experimental pharmacology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Peter C DumoulinDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, United States.ORCID 0000-0003-4377-0964
Joshua VollrathDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, United States.ORCID 0000-0002-6673-3050
Sheena Shah TomkoDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, United States.
Jennifer X WangHarvard Center for Mass Spectrometry, Harvard University, Cambridge, United States.
Barbara BurleighDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, United States.ORCID 0000-0002-3642-7247
Harvard University · US

Funding

Exploring metabolic resistance to small molecule inhibitors in Trypanosoma cruziR21AI146815 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI BURLEIGH, BARBARA A · 2019 to 2020
$439k
American Heart Association 19POST34380209Deutscher Akademischer Austauschdienst PROMOSNIAID NIH HHS R21 AI146815
6 · The paper itself

Abstract

The mechanisms underlying resistance of the Chagas disease parasite,

Indexed as

14-alpha Demethylase InhibitorsAnimalsAzolesCell LineChagas DiseaseDrug InteractionsDrug ResistanceErgosterolGlutamineHumansKetoconazoleTrypanocidal AgentsTrypanosoma cruzi14-alpha Demethylase InhibitorsAzolesErgosterolGlutamineKetoconazoleTrypanocidal Agentsdrug resistanceinfectious diseasemetabolismmicrobiologysterol biosynthesisTrypanosoma cruzi

Identifiers

PMID33258448
PMCPMC7707839
OpenAlexW3107306012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.