Evidence map›Paper›PMID 33258446›Full record

ArticleeLife2020

Isabelle Schmutz, Arjen R Mensenkamp, Kaori K Takai, Maaike Haadsma, Liesbeth Spruijt, Richarda M de Voer, Seunga Sara Choo, Franziska K Lorbeer, Emma J van Grinsven, Dirk Hockemeyer and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 57 citations in OpenAlex.

  1. Trial
  2. How telomere attrition protects against cancer.Nature reviews. Genetics · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Melatonin and Breast Cancer: A Review Article.Chonnam medical journal · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Isabelle SchmutzLaboratory for Cell Biology and Genetics, Rockefeller University, New York, United States.ORCID 0000-0001-7193-3922
Arjen R MensenkampDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands.ORCID 0000-0003-3805-877X
Kaori K TakaiLaboratory for Cell Biology and Genetics, Rockefeller University, New York, United States.
Maaike HaadsmaDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands.
Liesbeth SpruijtDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands.
Richarda M de VoerDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands.
Seunga Sara ChooDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, United States.
Franziska K LorbeerDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-3152-6852
Emma J van GrinsvenDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, United States.
Dirk HockemeyerDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-5598-5092
Marjolijn Cj JongmansDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands.
Titia de LangeLaboratory for Cell Biology and Genetics, Rockefeller University, New York, United States.ORCID 0000-0002-9267-367X
Radboud University Nijmegen · NLRockefeller University · USUniversity of California, Berkeley · USChan Zuckerberg Initiative (United States) · US

Funding

Genome instability in cancer: telomeres and DNA repairR35CA210036 · NCI · ROCKEFELLER UNIVERSITY · PI Titia de Lange · 2016 to 2026
$10.8M
Telomerase function in human tumor and stem cell biologyR01CA196884 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HOCKEMEYER, DIRK · 2015 to 2019
$1.7M
Melanoma Research Alliance 577521NCI NIH HHS R01 CA196884NCI NIH HHS R35 CA210036
6 · The paper itself

Abstract

Telomere shortening is a presumed tumor suppressor pathway that imposes a proliferative barrier (the Hayflick limit) during tumorigenesis. This model predicts that excessively long somatic telomeres predispose to cancer. Here, we describe cancer-prone families with two unique

Indexed as

Genes, Tumor SuppressorCell LineFemaleHEK293 CellsHeterozygoteHumansLoss of Function MutationMaleNeoplasmsTelomereTelomere-Binding ProteinsTelomere ShorteningTelomeric Repeat Binding Protein 1Tumor Suppressor ProteinsTelomere-Binding ProteinsTelomeric Repeat Binding Protein 1TINF2 protein, humanTumor Suppressor Proteinscancer biologycancer predispositionhumantelomere lengthTIN2

Identifiers

PMID33258446
PMCPMC7707837
OpenAlexW3108172094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.