Evidence map›Paper›PMID 33258416›Full record

ArticleVirulence2020

SarA plays a predominant role in controlling the production of extracellular proteases in the diverse clinical isolates of

Aura M Ramirez, Karen E Beenken, Stephanie D Byrum, Alan J Tackett, Lindsey N Shaw, Brittney D Gimza, Mark S Smeltzer

Open access · goldAbstract read
In one paragraph

Article in Virulence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Monoclonal antibody neutralizesInfection and immunity · 2025
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  6. Microorganisms · 2025
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  7. The ability ofInfection and immunity · 2025
    Article
  8. Microorganisms · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. The major role ofVirulence · 2023
    Article
  13. Review
  14. Article
  15. Tannin extracted fromFrontiers in microbiology · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Screening transcriptional connections inMicrobiology (Reading, England) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Aura M RamirezDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences , Little Rock, AR, USA.
Karen E BeenkenDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences , Little Rock, AR, USA.
Stephanie D ByrumDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, and Arkansas Children's Research Institute , Little Rock, AR, USA.ORCID 0000-0002-1783-3610
Alan J TackettDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, and Arkansas Children's Research Institute , Little Rock, AR, USA.
Lindsey N ShawDepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida , Tampa, FL.
Brittney D GimzaDepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida , Tampa, FL.
Mark S SmeltzerDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences , Little Rock, AR, USA.
University of Arkansas for Medical Sciences · USArkansas Children's Hospital · USUniversity of South Florida · US

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9M
Translational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Alan Tackett, Sean D. Taverna · 2017 to 2026
$27.6M
Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
Pilot Grant ProgramP30GM145393 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Jason S Stumhofer · 2022 to 2026
$7.6M
Impact of Staphylococcus aureus in osteomyelitis and bone physiologyR01AI119380 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI BEENKEN, KAREN E., SMELTZER, MARK S · 2015 to 2025
$4.1M
Center for Protein Structure and FunctionP30GM103450 · NIGMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI MILLETT, FRANCIS S · 2012 to 2014
$3.2M
The Role and Regulation of Extracellular Proteases in Staphylococcus aureusR01AI124458 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SHAW, LINDSEY NEIL · 2017 to 2020
$1.7M
Orbitrap Fusion Tribrid Mass SpectrometerS10OD018445 · OD · UNIV OF ARKANSAS FOR MED SCIS · PI MACKINTOSH, SAMUEL G. · 2015 to 2015
$856k
NCATS NIH HHS UL1 TR000039NIAID NIH HHS R01 AI119380NIAID NIH HHS R01 AI124458NIGMS NIH HHS P20 GM103429NIGMS NIH HHS P20 GM121293NIGMS NIH HHS P30 GM103450NIGMS NIH HHS P30 GM145393NIH HHS S10 OD018445
6 · The paper itself

Abstract

Using DNA affinity chromatography we demonstrate that the

Indexed as

Bacterial ProteinsBacterial ToxinsBiofilmsGene Expression Regulation, BacterialHumansMetalloendopeptidasesMutationOsteoblastsOsteoclastsPeptide HydrolasesPhenotypeStaphylococcal InfectionsStaphylococcus aureusTrans-ActivatorsVirulenceVirulence FactorsaureolysinBacterial ProteinsBacterial ToxinsMetalloendopeptidasesPeptide HydrolasesSarA protein, bacterialTrans-ActivatorsVirulence Factorsbiofilmextracellular proteasemgrAregulationrotsarAsarRsarSsarZStaphylococcus aureus

Identifiers

PMID33258416
PMCPMC7738309
OpenAlexW3109975993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.