Evidence map›Paper›PMID 33258202›Full record

ArticleNMR in biomedicine2021

Comparison of in vivo and in situ detection of hippocampal metabolites in mouse brain using

Chao-Hsiung Hsu, Stephen Lin, Ai-Chen Ho, T Derek Johnson, Paul C Wang, Joseph Scafidi, Tsang-Wei Tu

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. The multifaceted roles of the brain glycogen.Journal of neurochemistry · 2024
    Review
  3. Article
  4. Cell reports methods · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Chao-Hsiung HsuMolecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC, USA.ORCID 0000-0002-6213-4931
Stephen LinMolecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC, USA.
Ai-Chen HoMolecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC, USA.
T Derek JohnsonCenter for Neuroscience Research, Department of Neurology, Children's National Hospital, Washington, DC, USA.
Paul C WangMolecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC, USA.ORCID 0000-0001-8219-7051
Joseph ScafidiCenter for Neuroscience Research, Department of Neurology, Children's National Hospital, Washington, DC, USA.ORCID 0000-0003-2379-1370
Tsang-Wei TuMolecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC, USA.ORCID 0000-0002-5070-0465
Howard University · USChildren's National · USFu Jen Catholic University · TW

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
Sleep Disorders in Adults with Sickle Cell Disease: Frequency, Associations with Cardiovascular and Pain Indicators, and Responses to TreatmentU54MD007597 · NIMHD · HOWARD UNIVERSITY · PI Tatiana V.D. Sanses · 2019 to 2026
$37.7M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI HOFFMAN, ERIC P. · 2016 to 2020
$5.9M
Bioenergetic Failure Underlies Cerebral Dysmaturity After Perinatal Brain InjuryR01NS099461 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCAFIDI, JOSEPH · 2017 to 2021
$1.9M
NCATS NIH HHS UL1 TR001409NICHD NIH HHS U54 HD090257NIMHD NIH HHS U54 MD007597NINDS NIH HHS R01 NS099461
6 · The paper itself

Abstract

The study of cerebral metabolites relies heavily on detection methods and sample preparation. Animal experiments in vivo require anesthetic agents that can alter brain metabolism, whereas ex vivo experiments demand appropriate fixation methods to preserve the tissue from rapid postmortem degradation. In this study, the metabolic profiles of mouse hippocampi using proton magnetic resonance spectroscopy (

Indexed as

AnimalsBody WaterFemaleHippocampusLipidsMagnetic Resonance SpectroscopyMaleMiceMice, Inbred C57BLMicrowavesNeuroimagingPostmortem ChangesProton Magnetic Resonance SpectroscopyRandom AllocationTissue FixationLipids1H-MRSFBMIhippocampal metabolitesmicrowave fixationmouse brainpostmortem degradation

Identifiers

PMID33258202
PMCPMC8214416
OpenAlexW3109500658

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.