ArticleAnnals of biomedical engineering2021
Brain Strain: Computational Model-Based Metrics for Head Impact Exposure and Injury Correlation.
Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Head Impacts and Acceleration Associated with Soccer.International journal of environmental research and public health · 2022Pooled it
- Regional ventricular enlargement as an in vivo biomarker of cumulative biomechanical neurodegeneration in former American football players.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Effect of modeling subject-specific cortical folds on brain injury risk prediction under blunt impact loading.Biomechanics and modeling in mechanobiology · 2026Article
- Correlating Magnetoencephalography, Diffusion Kurtosis Imaging, Biomechanics, and Neuropsychology in American Youth Football.Journal of neurotrauma · 2025Article
- Neuromechanical Models of Mild Traumatic Brain Injury Conditioned on Reaction Time: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Investigation of Head Kinematics and Brain Strain Response During Soccer Heading Using a Custom-Fit Instrumented Mouthguard.Annals of biomedical engineering · 2024Article
- A Novel Experimental Approach for the Measurement of Vibration-Induced Changes in the Rheological Properties of Ex Vivo Ovine Brain Tissue.Sensors (Basel, Switzerland) · 2024Article
- Position-based assessment of head impact frequency, severity, type, and location in high school American football.Frontiers in bioengineering and biotechnology · 2024Article
- Image-based axon model highlights heterogeneity in initiation of damage.Biophysical journal · 2023Article
- Soccer's AI transformation: deep learning's analysis of soccer's pandemic research evolution.Frontiers in psychology · 2023Article
- Use of Brain Biomechanical Models for Monitoring Impact Exposure in Contact Sports.Annals of biomedical engineering · 2022Review
- American Football Helmet Effectiveness Against a Strain-Based Concussion Mechanism.Annals of biomedical engineering · 2022Article
- Real-time dynamic simulation for highly accurate spatiotemporal brain deformation from impact.Computer methods in applied mechanics and engineering · 2022Article
- Cumulative strain-based metrics for predicting subconcussive head impact exposure-related imaging changes in a cohort of American youth football players.Journal of neurosurgery. Pediatrics · 2022Article
- Age-Related Trajectories of Brain Structure-Function Coupling in Female Roller Derby Athletes.Brain sciences · 2021Article
- Time Window of Head Impact Kinematics Measurement for Calculation of Brain Strain and Strain Rate in American Football.Annals of biomedical engineering · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Athletes participating in contact sports are exposed to repetitive subconcussive head impacts that may have long-term neurological consequences. To better understand these impacts and their effects, head impacts are often measured during football to characterize head impact exposure and estimate injury risk. Despite widespread use of kinematic-based metrics, it remains unclear whether any single metric derived from head kinematics is well-correlated with measurable changes in the brain. This shortcoming has motivated the increasing use of finite element (FE)-based metrics, which quantify local brain deformations. Additionally, quantifying cumulative exposure is of increased interest to examine the relationship to brain changes over time. The current study uses the atlas-based brain model (ABM) to predict the strain response to impacts sustained by 116 youth football athletes and proposes 36 new, or derivative, cumulative strain-based metrics that quantify the combined burden of head impacts over the course of a season. The strain-based metrics developed and evaluated for FE modeling and presented in the current study present potential for improved analytics over existing kinematically-based and cumulative metrics. Additionally, the findings highlight the importance of accounting for directional dependence and expand the techniques to explore spatial distribution of the strain response throughout the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.