Evidence map›Paper›PMID 33258071›Full record

ReviewBasic research in cardiology2020

Cellular and mitochondrial mechanisms of atrial fibrillation.

Fleur E Mason, Julius Ryan D Pronto, Khaled Alhussini, Christoph Maack, Niels Voigt

Open access · hybridAbstract readReview
In one paragraph

Review in Basic research in cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Fleur E MasonInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.
Julius Ryan D ProntoInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.
Khaled AlhussiniDepartment of Thoracic and Cardiovascular Surgery, University Clinic Würzburg, Würzburg, Germany.
Christoph MaackDepartment of Translational Research, Comprehensive Heart Failure Center Würzburg, University Clinic Würzburg, Am Schwarzenberg 15, 97078, Würzburg, Germany. Maack_C@ukw.de.ORCID 0000-0003-3694-4559
Niels VoigtInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany. niels.voigt@med.uni-goettingen.de.ORCID 0000-0001-8230-2341
Universitätsmedizin Göttingen · DEGerman Centre for Cardiovascular Research · DEUniversitätsklinikum Würzburg · DEUniversity of Würzburg · DE

Funding

Bundesministerium für Bildung und Forschung 01EO1504Bundesministerium für Bildung und Forschung BMBFDeutsche Forschungsgemeinschaft EXC 2067/1- 390729940Deutsche Forschungsgemeinschaft IRTG1816Deutsche Forschungsgemeinschaft Ma 2528/7-1Deutsche Forschungsgemeinschaft SFB1002Deutsche Forschungsgemeinschaft SFB 894Deutsche Forschungsgemeinschaft TRR-219Deutsche Forschungsgemeinschaft VO 1568/3-1Deutsches Zentrum für Herz-Kreislaufforschung DZHK GOE MD3Deutsches Zentrum für Herz-Kreislaufforschung SE181Else Kröner-Fresenius-Stiftung EKFS 2016_A20
6 · The paper itself

Abstract

The molecular mechanisms underlying atrial fibrillation (AF), the most common form of arrhythmia, are poorly understood and therefore target-specific treatment options remain an unmet clinical need. Excitation-contraction coupling in cardiac myocytes requires high amounts of adenosine triphosphate (ATP), which is replenished by oxidative phosphorylation in mitochondria. Calcium (Ca

Indexed as

Atrial FunctionHeart RateAnimalsAtrial FibrillationCalcium SignalingEnergy MetabolismHeart AtriaHumansMitochondria, HeartMyocytes, CardiacOxidative StressReactive Oxygen SpeciesReactive Oxygen SpeciesAtrial cardiomyopathyAtrial fibrillationCalciumElectrophysiologyMitochondriaOxidative stress

Identifiers

PMID33258071
PMCPMC7704501
OpenAlexW3108432341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.