Evidence map›Paper›PMID 33258065›Full record

ArticleInternational journal of implant dentistry2020

Gene expression, immunohistochemical and microarchitectural evaluation of bone formation around two implant surfaces placed in bone defects filled or not with bone substitute material.

Guilherme Dos Santos Trento, Jaqueline Suemi Hassumi, Paula Buzo Frigério, Ana Paula Farnezi Bassi, Roberta Okamoto, Marisa Aparecida Cabrini Gabrielli, Valfrido Antonio Pereira-Filho

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of implant dentistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Guilherme Dos Santos TrentoDepartment of Diagnosis and Surgery, School of Dentistry, Sao Paulo State University (Unesp), 1680th Humaitá Street, Araraquara, SP, 14801-903, Brazil. guilherme.s.trento@gmail.com.
Jaqueline Suemi HassumiDepartment of Oral and Maxillofacial Surgery, School of Dentistry, São Paulo State University (Unesp), Araçatuba, Brazil.
Paula Buzo FrigérioDepartment of Oral and Maxillofacial Surgery, School of Dentistry, São Paulo State University (Unesp), Araçatuba, Brazil.
Ana Paula Farnezi BassiDepartment of Oral and Maxillofacial Surgery, School of Dentistry, São Paulo State University (Unesp), Araçatuba, Brazil.
Roberta OkamotoDepartment of Oral and Maxillofacial Surgery, School of Dentistry, São Paulo State University (Unesp), Araçatuba, Brazil.
Marisa Aparecida Cabrini GabrielliDepartment of Diagnosis and Surgery, School of Dentistry, Sao Paulo State University (Unesp), 1680th Humaitá Street, Araraquara, SP, 14801-903, Brazil.
Valfrido Antonio Pereira-FilhoDepartment of Diagnosis and Surgery, School of Dentistry, Sao Paulo State University (Unesp), 1680th Humaitá Street, Araraquara, SP, 14801-903, Brazil.
Universidade Estadual Paulista (Unesp) · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/07837-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/04017-6
6 · The paper itself

Abstract

objectiveThe aim of this study is to evaluate through gene expression, immunohistochemical and microtomographic (micro-CT) analysis the response of peri-implant bone tissue around titanium implants with different surface treatments, placed in bone defects filled or not with bone substitute materials. In addition, to investigate the hypothesis that porous-hydrophilic surface induces a faster bone formation. MATERIALS AND

methodsTwenty-six animals were divided into two groups according to implant surface treatment. In each tibia, a bone defect was created followed by the placement of one implant. On the left tibia, the defect was filled with blood clot (BC), and on the right tibia, the defect was filled with biphasic hydroxyapatite/β-tricalcium-phosphate (HA/TCP) generating four subgroups: BC-N: bone defect filled with blood clot and porous surface titanium implant installed; BC-A: bone defect filled with blood clot and porous-hydrophilic surface titanium implant installed; HA/TCP-N: bone defect filled with bone substitute material and porous surface titanium implant installed; and HA/TCP-A: bone defect filled with bone substitute material and porous-hydrophilic surface titanium implant installed. The animals were submitted to euthanasia at 15, 30, and 60 days after implant installation. The expression of two genes was evaluated: RUNX2 and BSP. Immunohistochemical analyses were performed for detection of RUNX2, OPN, OCN, OPG, and RANKL antibodies and bone matrix proteins. Finally, four parameters were chosen for micro-CT analysis: trabecular number, separation and thickness, and connectivity density.

resultsDescriptive analysis showed similar findings among the experimental groups. Moreover, porous-hydrophilic surfaces presented a higher expression of RUNX2, which is probably an indicative of better osteogenesis; although the data from this study may be considered an insufficient support for a concrete statement.

conclusionPorous hydrophilic surface can improve and accelerate protein expression and bone formation.

Indexed as

Bone graftingCell viabilityOsseointegrated dental implantation

Identifiers

PMID33258065
PMCPMC7704835
OpenAlexW3109870667

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.