ArticleClinical chemistry2021
Long-Term Longitudinal Stability of Kidney Filtration Marker Measurements: Implications for Epidemiological Studies and Clinical Care.
Article in Clinical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Optimal Frequency of Urinary Albumin Screening in Type 1 Diabetes.Diabetes care · 2022Trial
- Combining Cystatin C and Creatinine Increases eGFR Slope Accuracy in ADPKD.Kidney international reports · 2026Article
- Glomerular filtration rate estimation in nephrotic patients: creatinine and/or cystatin-C-based equations, or none of them?Clinical kidney journal · 2026Article
- Total kidney volume as a predictor of measured glomerular filtration rate in patients with solid tumors: a prospective cross-sectional analysis.Journal of nephrology · 2025Article
- Renal Arteriovenous Gradients for Greater Than 10,000 Circulating Proteins.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Article
- Pseudo acute kidney injury in patients receiving CDK4/6 inhibitors.British journal of cancer · 2025Article
- Article
- Early Trajectory of Estimated Glomerular Filtration Rate and Long-term Advanced Kidney and Cardiovascular Complications in Type 1 Diabetes.Diabetes care · 2022Article
- Aging and its treatment with vitamin C: a comprehensive mechanistic review.Molecular biology reports · 2021Review
- New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race.The New England journal of medicine · 2021Article
- Reassessing the Inclusion of Race in Diagnosing Kidney Diseases: An Interim Report From the NKF-ASN Task Force.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Article
- Reassessing the Inclusion of Race in Diagnosing Kidney Diseases: An Interim Report from the NKF-ASN Task Force.Journal of the American Society of Nephrology : JASN · 2021Article
- A New Panel-Estimated GFR, Including βAmerican journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundEstablishment and improvement of glomerular filtration rate estimating equations requires accurate and precise laboratory measurement procedures (MPs) for filtration markers. The Advanced Research and Diagnostic Laboratory (ARDL) at the University of Minnesota, which has served as the central laboratory for the Chronic Kidney Disease Epidemiology Collaboration since 2009, has implemented several quality assurance measures to monitor the accuracy and stability of filtration marker assays over time.
methodsTo assess longitudinal stability for filtration marker assays, a 40-sample calibration panel was created using pooled serum, divided into multiple frozen aliquots stored at -80 °C. ARDL monitored 4 markers-creatinine, cystatin C, beta-2-microglobulin (B2M) and beta-trace protein-measuring 15 calibration panel aliquots from 2009 to 2019. Initial target values were established using the mean of the first 3 measurements performed in 2009-10, and differences from target were monitored over time. New MPs for cystatin C and B2M were added in 2012, with target values established using the first measurement.
resultsThe mean percentage difference from mean target values across time was <2% for all original MPs (-0.59% for creatinine; -0.94% for cystatin C; -0.82% for B2M; 1.24% for beta-trace protein).
conclusionsClose monitoring of filtration marker trends with a calibration panel at ARDL demonstrates remarkable long-term stability of the MPs. Routine use of a calibration panel for both research studies and clinical care is recommended for filtration markers where longitudinal monitoring is important to detect analytical biases, which can mask or confound true clinical trends in patients.
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Registered trials
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