Evidence map›Paper›PMID 33257809›Full record

ArticleCommunications biology2020

Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster.

Yoshiki Higashijima, Nao Nagai, Masamichi Yamamoto, Taro Kitazawa, Yumiko K Kawamura, Akashi Taguchi, Natsuko Nakada, Masaomi Nangaku, Tetsushi Furukawa, Hiroyuki Aburatani and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Large-scale mouse mutagenesis identifies novel genes affecting vertebral anatomy.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
  2. Article
  3. How does oxytocin modulate human behavior?Molecular psychiatry · 2025
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 4 countries.

Yoshiki HigashijimaDepartment of Bioinformational Pharmacology, Tokyo Medical and Dental University, Tokyo, 113-8510, Japan.ORCID 0000-0002-4489-606X
Nao NagaiDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Masamichi YamamotoDepartment of Nephrology, Kyoto University Graduate School of Medicine, Kyoto University Hospital, Shogoin-Kawaramachi-cho, Sakyo-ward, Kyoto, 606-8507, Japan.
Taro KitazawaFriedrich Miescher Institute for Biomedical Research, Basel, 4051, Switzerland.
Yumiko K KawamuraFriedrich Miescher Institute for Biomedical Research, Basel, 4051, Switzerland.
Akashi TaguchiIsotope Science Center, The University of Tokyo, Tokyo, 113-0032, Japan.
Natsuko NakadaIsotope Science Center, The University of Tokyo, Tokyo, 113-0032, Japan.
Masaomi NangakuDivision of Nephrology and Endocrinology, The University of Tokyo, 113-0033, Tokyo, Japan.
Tetsushi FurukawaDepartment of Bioinformational Pharmacology, Tokyo Medical and Dental University, Tokyo, 113-8510, Japan.
Hiroyuki AburataniDivision of Genome Science, RCAST, The University of Tokyo, Tokyo, 153-8904, Japan.
Hiroki KuriharaDepartment of Physiological Chemistry and Metabolism, The University of Tokyo, Tokyo, 113-0033, Japan.
Youichiro WadaIsotope Science Center, The University of Tokyo, Tokyo, 113-0032, Japan.
Yasuharu KankiIsotope Science Center, The University of Tokyo, Tokyo, 113-0032, Japan. kanki@lsbm.org.ORCID 0000-0002-3795-3919
The University of Tokyo · JPFriedrich Miescher Institute · CHDepartment of Physiological Sciences · RUKeio University · JPNational Cerebral and Cardiovascular Center · JPTokyo Medical and Dental University · JPTokyo University of Science · JPUniversity of Copenhagen · DKUniversity of Tokyo Hospital · JPUniversity of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Temporal and spatial colinear expression of the Hox genes determines the specification of positional identities during vertebrate development. Post-translational modifications of histones contribute to transcriptional regulation. Lysine demethylase 7A (Kdm7a) demethylates lysine 9 or 27 di-methylation of histone H3 (H3K9me2, H3K27me2) and participates in the transcriptional activation of developmental genes. However, the role of Kdm7a during mouse embryonic development remains to be elucidated. Herein, we show that Kdm7a

Indexed as

Jumonji Domain-Containing Histone DemethylasesAnimalsEmbryo, MammalianEmbryonic DevelopmentFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxHeLa CellsHumansMaleMiceMice, Inbred C57BLMice, Inbred ICRMice, KnockoutMultigene FamilyJumonji Domain-Containing Histone DemethylasesKDM7 protein, mouse

Identifiers

PMID33257809
PMCPMC7704666
OpenAlexW3107589351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.