ArticleScientific reports2020
Trajectories of depressive symptoms and associated patterns of cognitive decline.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Systematic Review of Available Normative Data on Neuropsychological Tests for Spanish Speakers in the U.S., Latin America and the Caribbean, and Spain.Neuropsychology review · 2026Pooled it
- Cognitive impairment in psoriasis patients: a systematic review of case-control studies.Journal of neurology · 2022Pooled it
- Long-term depressive symptom trajectories and related baseline characteristics in primary care patients: Analysis of the PsicAP clinical trial.European psychiatry : the journal of the Association of European Psychiatrists · 2024Trial
- Positive affect disrupts neurodegeneration effects on cognitive training plasticity in older adults.Social cognitive and affective neuroscience · 2024Trial
- Possible and Probable Dementia and Depressive/Anxiety Symptoms in U.S. Older Adults: One-Year Follow-Up.Journal of aging and health · 2026Article
- Life's Simple 7, depressive symptoms, cognitive performance, and their associations with all-cause mortality among middle-aged urban adults.GeroScience · 2026Article
- Neuropsychological Correlates of Anxiety in Older Adults: A Cross-Sectional Comparison with Controls Without a Psychiatric Diagnosis.Brain sciences · 2026Article
- No Cognitive Scarring Over 20 Years in Recurrent Depression: Bidirectionality of Cognitive Functioning and Depression.Clinical psychology in Europe · 2026Article
- Childhood maltreatment and joint trajectories of social isolation and depression as predictors of cognitive impairment in late midlife: a prospective cohort study.Epidemiology and psychiatric sciences · 2026Article
- Depressive symptom instability predicts incident mild cognitive impairment and dementia in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Two steps forward, one step back: cohort shifts in cognitive function trajectories in aging European populations.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Article
- Prioritizing Neurocognitive and Psychosocial Outcomes in Adults With Congenital Heart Disease: A Consensus Statement From the Adults With Congenital Heart Disease/Neuro 2024 Conference.Journal of the American Heart Association · 2026Article
- Associations between mental health and cognitive function among community-dwelling older adults: a large-scale cross-sectional study.BMC public health · 2026Article
- The association between internet use and cognition in older adults: empirical analysis based on CLASS 2023.Frontiers in psychology · 2026Article
- Latent profile analysis of depressive symptoms among Chinese older adults with disabilities and associated factors.Frontiers in psychiatry · 2026Article
- Five depressive symptom trajectories in three dimensions are risk factors of cancer: a ten-year follow-up study.Archives of public health = Archives belges de sante publique · 2025Article
- Depressive Symptoms Affect Cognitive Functioning from Middle to Late Adulthood: Ethnoracial Minorities Experience Greater Repercussions.Journal of racial and ethnic health disparities · 2025Article
- Exploring the mediating roles of depression and cognitive function in the association between sarcopenia and frailty: A Cox survival analysis approach.Journal of advanced research · 2025Article
- Depressive symptoms and chronic disease trajectories and predictors in middle-aged and older adults in China: An eight-year multi-trajectory analysis.Global health & medicine · 2025Article
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7 authors.
Funding
Abstract
The aim was to investigate the pattern and rate of cognitive decline across distinctive trajectories of depressive symptoms in older adults. In this prospective multinational cohort study on 69,066 participants (on average 64 years at baseline, 55% women), assessments of cognitive functions (immediate recall, delayed recall, verbal fluency) and depressive symptoms (EURO-D scale) were conducted at 2-year intervals. The trajectories of depressive symptoms were obtained using latent growth mixture modelling, cognitive decline was assessed using smoothing splines and linear mixed effects models. Four distinct trajectories of depressive symptoms were identified: constantly low (n = 49,660), constantly high (n = 2999), increasing (n = 6828) and decreasing (n = 9579). Individuals with increasing and constantly high depressive symptoms showed linear cognitive decline, while those with constantly low and decreasing depressive symptoms had fluctuating cognition. Participants with increasing depressive symptoms had the fastest decline, while those with decreasing symptoms were spared from decline in cognition. This study suggests that the pattern as well as the rate of cognitive decline co-occurs with specific patterns of changes in depressive symptoms over time. The most pronounced cognitive decline is present in individuals, in whom depressive symptoms increase late in life. Unique mechanisms of cognitive decline may exist for subgroups of the population, and are associated with the trajectory of depressive symptoms.
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