ArticleNature communications2020
Spatially expandable fiber-based probes as a multifunctional deep brain interface.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 98 citations in OpenAlex.
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- Nanophotonic neural probes for in vivo photostimulation, electrophysiology, and microfluidic delivery.Microsystems & nanoengineering · 2026Article
- Multi-Channel Neural Interface for Neural Recording and Neuromodulation.Small methods · 2026Review
- Laser-engineered PRIME fiber for panoramic reconfigurable control of neural activity.Nature neuroscience · 2026Article
- Monolithic multimodal neural probes for sustained stimulation and long-term neural recording.Science advances · 2025Article
- Recent Advances in Stimuli-Responsive Materials and Soft Robotic Actuators for Bioelectronic Medicine.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Phase-change metal ink with pH-controlled chemical sintering for versatile and scalable fabrication of variable stiffness electronics.Science advances · 2025Article
- Human-Centric, Three Dimensional Micro Light-Emitting Diodes for Cosmetic and Medical Phototherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Magnetically reshapable 3D multi-electrode arrays of liquid metals for electrophysiological analysis of brain organoids.Nature communications · 2025Article
- Anisotropic hydrogel microelectrodes for intraspinal neural recordings in vivo.Nature communications · 2025Article
- Segmented, Side-Emitting Hydrogel Optical Fibers for Multimaterial Extrusion Printing.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Multifunctional Tetrode-like Drug delivery, Optical stimulation, and Electrophysiology (Tetro-DOpE) probes.Biosensors & bioelectronics · 2024Article
- Thermally Drawn Polymeric Catheters for MR-Guided Cardiovascular Intervention.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Flexible multimaterial fibers in modern biomedical applications.National science review · 2024Review
- Article
- Multifunctional and Flexible Neural Probe with Thermally Drawn Fibers for Bidirectional Synaptic Probing in the Brain.ACS nano · 2024Article
- Increased expression of chondroitin sulfate proteoglycans in dentate gyrus and amygdala causes postinfectious seizures.Brain : a journal of neurology · 2024Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
Understanding the cytoarchitecture and wiring of the brain requires improved methods to record and stimulate large groups of neurons with cellular specificity. This requires miniaturized neural interfaces that integrate into brain tissue without altering its properties. Existing neural interface technologies have been shown to provide high-resolution electrophysiological recording with high signal-to-noise ratio. However, with single implantation, the physical properties of these devices limit their access to one, small brain region. To overcome this limitation, we developed a platform that provides three-dimensional coverage of brain tissue through multisite multifunctional fiber-based neural probes guided in a helical scaffold. Chronic recordings from the spatially expandable fiber probes demonstrate the ability of these fiber probes capturing brain activities with a single-unit resolution for long observation times. Furthermore, using Thy1-ChR2-YFP mice we demonstrate the application of our probes in simultaneous recording and optical/chemical modulation of brain activities across distant regions. Similarly, varying electrographic brain activities from different brain regions were detected by our customizable probes in a mouse model of epilepsy, suggesting the potential of using these probes for the investigation of brain disorders such as epilepsy. Ultimately, this technique enables three-dimensional manipulation and mapping of brain activities across distant regions in the deep brain with minimal tissue damage, which can bring new insights for deciphering complex brain functions and dynamics in the near future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.