Evidence map›Paper›PMID 33257702›Full record

ArticleScientific reports2020

ELISA detection of SARS-CoV-2 antibodies in saliva.

Melanie A MacMullan, Albina Ibrayeva, Kylie Trettner, Laura Deming, Sudipta Das, Frances Tran, Jose Ricardo Moreno, Joseph G Casian, Prithivi Chellamuthu, Jeffrey Kraft and 4 more

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it.

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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Melanie A MacMullanCurative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
Albina IbrayevaCurative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
Kylie TrettnerCurative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
Laura DemingCurative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
Sudipta DasCurative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
Frances TranCurative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
Jose Ricardo MorenoCurative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
Joseph G CasianCurative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
Prithivi ChellamuthuCurative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
Jeffrey KraftCurative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
Kenneth KozakCurative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
Fred E TurnerCurative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
Vladimir I SlepnevCurative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA. Vlad.slepnev@curative.com.
Lydia M Le PageCurative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA. Lydia.mlp@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To facilitate containment of the COVID-19 pandemic currently active in the United States and across the world, options for easy, non-invasive antibody testing are required. Here we have adapted a commercially available, serum-based enzyme-linked immunosorbent assay (ELISA) for use with saliva samples, achieving 84.2% sensitivity and 100% specificity in a set of 149 clinical samples. This strategy will enable widespread, affordable testing for patients who experienced this disease, whilst minimizing exposure risk for healthcare workers.

Indexed as

Antibodies, ViralCarrier StateClinical Laboratory TechniquesCOVID-19COVID-19 Serological TestingEnzyme-Linked Immunosorbent AssayImmunoglobulin AImmunoglobulin GImmunoglobulin MSalivaSARS-CoV-2Sensitivity and SpecificityAntibodies, ViralImmunoglobulin AImmunoglobulin GImmunoglobulin M

Identifiers

PMID33257702
PMCPMC7705674

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.