Evidence map›Paper›PMID 33257700›Full record

ArticleNature communications2020

A clinically applicable deep-learning model for detecting intracranial aneurysm in computed tomography angiography images.

Zhao Shi, Chongchang Miao, U Joseph Schoepf, Rock H Savage, Danielle M Dargis, Chengwei Pan, Xue Chai, Xiu Li Li, Shuang Xia, Xin Zhang and 14 more

Abstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Application of convolutional network models in detection of intracranial aneurysms: A systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023
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  12. Anatomically-guided masked autoencoder pre-training for aneurysm detection.IEEE Winter Conference on Applications of Computer Vision. IEEE Winter Conference on Applications of Computer Vision · 2026
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Zhao ShiDepartment of Diagnostic Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, P.R. China.ORCID 0000-0002-9427-9609
Chongchang MiaoDepartment of Radiology, Lianyungang First People's Hospital, Lianyungang, Jiangsu, 222002, P.R. China.
U Joseph SchoepfDivision of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.
Rock H SavageDivision of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.
Danielle M DargisDivision of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.
Chengwei PanComputer Science Department, School of EECS, Peking University, Beijing, 100089, P.R. China.ORCID 0000-0003-0497-7903
Xue ChaiDepartment of Radiology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210002, P.R. China.
Xiu Li LiDeepWise AI lab., Beijing, 100089, P.R. China.
Shuang XiaDepartment of Radiology, Tianjin First Central Hospital, Tianjin, 300192, P.R. China.
Xin ZhangDepartment of Neurosurgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, P.R. China.
Yan GuDepartment of Radiology, Lianyungang First People's Hospital, Lianyungang, Jiangsu, 222002, P.R. China.
Yonggang ZhangDepartment of Radiology, Lianyungang First People's Hospital, Lianyungang, Jiangsu, 222002, P.R. China.
Bin HuDepartment of Diagnostic Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, P.R. China.
Wenda XuDepartment of Diagnostic Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, P.R. China.
Changsheng ZhouDepartment of Diagnostic Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, P.R. China.
Song LuoDepartment of Diagnostic Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, P.R. China.
Hao WangDeepWise AI lab., Beijing, 100089, P.R. China.
Li MaoDeepWise AI lab., Beijing, 100089, P.R. China.ORCID 0000-0002-5383-379X
Kongming LiangDeepWise AI lab., Beijing, 100089, P.R. China.
Lili WenDepartment of Neurosurgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, P.R. China.
Longjiang ZhouDepartment of Neurosurgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, P.R. China.
Yizhou YuDeepWise AI lab., Beijing, 100089, P.R. China.ORCID 0000-0002-0470-5548
Guang Ming LuDepartment of Diagnostic Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, P.R. China. cjr.luguangming@vip.163.com.ORCID 0000-0003-4913-2314
Long Jiang ZhangDepartment of Diagnostic Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, P.R. China. kevinzhlj@163.com.ORCID 0000-0002-6664-7224

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracranial aneurysm is a common life-threatening disease. Computed tomography angiography is recommended as the standard diagnosis tool; yet, interpretation can be time-consuming and challenging. We present a specific deep-learning-based model trained on 1,177 digital subtraction angiography verified bone-removal computed tomography angiography cases. The model has good tolerance to image quality and is tested with different manufacturers. Simulated real-world studies are conducted in consecutive internal and external cohorts, in which it achieves an improved patient-level sensitivity and lesion-level sensitivity compared to that of radiologists and expert neurosurgeons. A specific cohort of suspected acute ischemic stroke is employed and it is found that 99.0% predicted-negative cases can be trusted with high confidence, leading to a potential reduction in human workload. A prospective study is warranted to determine whether the algorithm could improve patients' care in comparison to clinicians' assessment.

Indexed as

Deep LearningAgedAlgorithmsAngiography, Digital SubtractionBrain IschemiaChinaComputed Tomography AngiographyFemaleHumansImaging, Three-DimensionalIntracranial AneurysmMaleMiddle AgedProspective StudiesSensitivity and SpecificityStroke

Identifiers

PMID33257700
PMCPMC7705757

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.