Evidence map›Paper›PMID 33257694›Full record

ArticleScientific reports2020

Pharmacological targeting of c-FLIP

Corinna König, Laura K Hillert-Richter, Nikita V Ivanisenko, Vladimir A Ivanisenko, Inna N Lavrik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Pharmacological targeting of caspase-8/c-FLIPCommunications biology · 2025
    Article
  3. Targeting caspase-8/c-FLIPFrontiers in cell and developmental biology · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Corinna KönigTranslational Inflammation Research, Medical Faculty, CDS, Otto von Guericke University Magdeburg, 39106, Magdeburg, Germany.
Laura K Hillert-RichterTranslational Inflammation Research, Medical Faculty, CDS, Otto von Guericke University Magdeburg, 39106, Magdeburg, Germany.
Nikita V IvanisenkoFederal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Prospekt Lavrentyeva 10, Novosibirsk, 630090, Russia.
Vladimir A IvanisenkoFederal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Prospekt Lavrentyeva 10, Novosibirsk, 630090, Russia.
Inna N LavrikTranslational Inflammation Research, Medical Faculty, CDS, Otto von Guericke University Magdeburg, 39106, Magdeburg, Germany. inna.lavrik@med.ovgu.de.
Otto-von-Guericke University Magdeburg · DEInstitute of Cytology and Genetics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of efficient combinatorial treatments is one of the key tasks in modern anti-cancer therapies. An apoptotic signal can either be induced by activation of death receptors (DR) (extrinsic pathway) or via the mitochondria (intrinsic pathway). Cancer cells are characterized by deregulation of both pathways. Procaspase-8 activation in extrinsic apoptosis is controlled by c-FLIP proteins. We have recently reported the small molecules FLIPinB/FLIPinBγ targeting c-FLIP

Indexed as

Aniline CompoundsAntineoplastic Combined Chemotherapy ProtocolsApoptosisCASP8 and FADD-Like Apoptosis Regulating ProteinCaspase 8Cell SurvivalDeath Domain Receptor Signaling Adaptor ProteinsDrug Delivery SystemsFas Ligand ProteinHeLa CellsHumansProto-Oncogene Proteins c-bcl-2SulfonamidesAniline CompoundsBCL2 protein, humanCASP8 and FADD-Like Apoptosis Regulating ProteinCASP8 protein, humanCaspase 8CFLAR protein, humanDeath Domain Receptor Signaling Adaptor ProteinsFas Ligand ProteinnavitoclaxProto-Oncogene Proteins c-bcl-2Sulfonamides

Identifiers

PMID33257694
PMCPMC7705755
OpenAlexW3108452386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.