Evidence map›Paper›PMID 33257678›Full record

ArticleNature communications2020

CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer.

Man Zhang, Wei Yang, Peng Wang, Yu Deng, Yu-Ting Dong, Fang-Fang Liu, Rui Huang, Peng Zhang, Ya-Qi Duan, Xin-Dong Liu and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 204 citations in OpenAlex.

  1. Review
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  3. Observational
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  6. Viral mimicry may help explain immunogenic cell death.Proceedings of the National Academy of Sciences of the United States of America · 2026
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Man ZhangDepartment of Gastrointestinal Surgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Wei YangDepartment of Gastrointestinal Surgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Peng WangDepartment of Gastrointestinal Surgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Yu DengDepartment of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Yu-Ting DongInstitute of Pathology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China.
Fang-Fang LiuDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Rui HuangInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 40038, China.
Peng ZhangDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Ya-Qi DuanInstitute of Pathology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China.
Xin-Dong LiuInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 40038, China.ORCID 0000-0002-2465-0337
Dandan LinCancer Center, Renmin Hospital of Wuhan University, Wuhan, 430061, China. lindandan@whu.edu.cn.ORCID 0000-0003-3843-6945
Qian ChuDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. qianchu@tjh.tjmu.edu.cn.ORCID 0000-0001-8192-7630
Bo ZhongDepartment of Gastrointestinal Surgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. zhongbo@whu.edu.cn.ORCID 0000-0002-3832-2895
Tongji Hospital · CNWuhan University · CNArmy Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficacy of checkpoint immunotherapy to non-small cell lung cancer (NSCLC) largely depends on the tumor microenvironment (TME). Here, we demonstrate that CCL7 facilitates anti-PD-1 therapy for the Kras

Indexed as

ImmunityAnimalsAntibodies, Monoclonal, HumanizedCarcinoma, Non-Small-Cell LungCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChemokine CCL7ChemokinesDisease Models, AnimalFemaleGenes, rasHumansImmunotherapyLung NeoplasmsMaleMiceAntibodies, Monoclonal, HumanizedatezolizumabCCL7 protein, humanCcl7 protein, mouseChemokine CCL7ChemokinesTP53 protein, humanTrp53 protein, mouseTumor Suppressor Protein p53

Identifiers

PMID33257678
PMCPMC7704643
OpenAlexW3107263663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.