Evidence map›Paper›PMID 33257596›Full record

ArticleAging2020

Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans.

Tze-Hong Wong, Ting-Yu Chen, Kuo-Yun Tseng, Zih-Ying Chen, Chung-Hsing Chen, Feng-Huei Lin, Hung-Ming Wu, Shankung Lin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Tze-Hong WongDepartment of Orthopedics, National Taiwan University Hospital, Hsin-Chu Branch, Taiwan, Republic of China.
Ting-Yu ChenInflammation Research and Drug Development Center, Changhua Christian Hospital, Taiwan, Republic of China.
Kuo-Yun TsengInstitute of Infectious Diseases and Vaccinology, National Health Research Institutes, Taiwan, Republic of China.
Zih-Ying ChenInflammation Research and Drug Development Center, Changhua Christian Hospital, Taiwan, Republic of China.
Chung-Hsing ChenInstitute of Population Health Sciences, National Health Research Institutes, Taiwan, Republic of China.
Feng-Huei LinInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taiwan, Republic of China.
Hung-Ming WuInflammation Research and Drug Development Center, Changhua Christian Hospital, Taiwan, Republic of China.
Shankung LinInflammation Research and Drug Development Center, Changhua Christian Hospital, Taiwan, Republic of China.
Changhua Christian Hospital · TWNational Health Research Institutes · TWChina Medical University · TWNational Taiwan University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging impairs the IGF-I signaling of bone marrow mesenchymal stem cells (bmMSCs), but the mechanism is unclear. Here, we found that the ability to auto-phosphorylate IGF-I receptor (IGF-IR) in response to IGF-I was decreased in the bmMSCs of aged donors. Conversely, data showed that decorin (DCN) expression was prominently increased in aged bmMSCs, and that under IGF-I treatment, DCN knockdown in serum-starved aged bmMSCs potentiated their mitogenic activity and IGF-IR auto-phosphorylation, whereas DCN overexpression in serum-starved adult bmMSCs decreased both activities. Co-immunoprecipitation assays suggested that IGF-I and DCN bound to IGF-IR in a competitive manner. Online MethPrimer predicted 4 CpG islands (CGIs) in the introns of

Indexed as

AdultAgedAgingAmino Acids, DicarboxylicBone Marrow CellsDecitabineDecorinDNA DemethylationDNA MethylationEnzyme InhibitorsGene Expression Regulation, DevelopmentalGene Knockdown TechniquesHumansInsulin-Like Growth Factor IMesenchymal Stem CellsMiddle AgedAmino Acids, DicarboxylicDCN protein, humanDecitabineDecorinEnzyme InhibitorsIGF1 protein, humanInsulin-Like Growth Factor IoxalylglycineReceptor, IGF Type 1RNA, Messengeragingbone marrow mesenchymal stem cellIGF-Iosteoporosissmall leucine-rich proteoglycan

Identifiers

PMID33257596
PMCPMC7835024
OpenAlexW3108903275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.