Evidence map›Paper›PMID 33257561›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Viewing rare conformations of the β

Michael T Lerch, Rachel A Matt, Matthieu Masureel, Matthias Elgeti, Kaavya Krishna Kumar, Daniel Hilger, Bryon Foys, Brian K Kobilka, Wayne L Hubbell

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. An Improved Cysteine-Based Labeling Strategy for GPCR Structural Dynamics Studies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  3. Elliptical β-barrel deformation underlies gating in VDAC1.Protein science : a publication of the Protein Society · 2026
    Article
  4. Advances in the Association Between theCurrent issues in molecular biology · 2026
    Review
  5. Atypical GPCR Activation Resolved by Nanobody Engineering.bioRxiv : the preprint server for biology · 2026
    Article
  6. Biased Allosteric Modulation in GPCR Drug Discovery.Handbook of experimental pharmacology · 2026
    Review
  7. Article
  8. The Allosteric Mechanism of G-Protein-Coupled Receptors is Induced Fit, Not Conformational Selection.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  9. Hydraulic Activation of the AsLOV2 Photoreceptor.bioRxiv : the preprint server for biology · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Protein Modeling with DEER Spectroscopy.Annual review of biophysics · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Michael T LerchJules Stein Eye Institute, University of California, Los Angeles, CA 90095.ORCID 0000-0002-8173-4879
Rachel A MattDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-9944-8897
Matthieu MasureelDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-4059-6166
Matthias ElgetiJules Stein Eye Institute, University of California, Los Angeles, CA 90095.ORCID 0000-0002-0550-4852
Kaavya Krishna KumarDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-2283-4033
Daniel HilgerDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0001-5179-1357
Bryon FoysDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
Brian K KobilkaDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305; kobilka@stanford.edu hubbellw@jsei.ucla.edu.ORCID 0000-0001-5958-3990
Wayne L HubbellJules Stein Eye Institute, University of California, Los Angeles, CA 90095; kobilka@stanford.edu hubbellw@jsei.ucla.edu.ORCID 0000-0003-0577-3312
Stanford University · USUniversity of California, Los Angeles · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xian-Jie Yang · 1985 to 2026
$16.8M
MOLECULAR BASIS OF MEMBRANE EXCITATIONR01EY005216 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HUBBELL, WAYNE L · 1985 to 2019
$9.8M
THE MECHANISM OF BETA2 ADRENOCEPTOR ACTIVATIONR01NS028471 · NINDS · STANFORD UNIVERSITY · PI KOBILKA, BRIAN K · 1990 to 2021
$6.7M
Regulation of β2-adrenergic receptor signaling by post-translational modificationsR01GM135581 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI LERCH, MICHAEL TAYLOR · 2019 to 2023
$1.7M
NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY005216NIGMS NIH HHS R01 GM135581NINDS NIH HHS R01 NS028471
6 · The paper itself

Abstract

The β

Indexed as

Magnetic Resonance SpectroscopyModels, MolecularPressureProtein Conformation, alpha-HelicalReceptors, Adrenergic, beta-2ThermodynamicsADRB2 protein, humanReceptors, Adrenergic, beta-2basal activityconformational selectiondouble electron–electron resonancehigh pressureβ2 adrenergic receptor

Identifiers

PMID33257561
PMCPMC7749303
OpenAlexW3110321636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.