ArticleProceedings of the National Academy of Sciences of the United States of America2020
Fouling-resistant zwitterionic polymers for complete prevention of postoperative adhesion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The trial behind it
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Who cites it
29 citing papers in PubMed.
- Hydrogel co-delivery of 5-fluorouracil and siRNA attenuates TGF-β1-mediated MMT to prevent postoperative peritoneal metastasis and adhesion in colorectal cancer.Asian journal of pharmaceutical sciences · 2026Article
- Design and Therapeutic Applications of Hydrogel Dressings in Diverse Wound Management.ACS omega · 2026Review
- Injectable gallic acid-engineered zwitterionic hydrogel for preventing postoperative adhesions in thyroid surgery through modulating oxidative stress and inflammation.Materials today. Bio · 2026Article
- Efficacy of Anti-Adhesive Barriers on Outcomes Following Pediatric Abdominal Surgery: A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Biomaterials in pancreatic surgery: progress and challenges in preoperative, intraoperative and postoperative care.Theranostics · 2026Review
- Novel injectable sodium alginate hydrogel developed for improved endometrial repair with human umbilical cord mesenchymal stem cells.Drug delivery and translational research · 2025Article
- An Injectable Zwitterionic Hydrogels with Multiple Intermolecular Interactions for Effective Prevention of Abdominal Adhesions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Postoperative Adhesions: Current Research on Mechanisms, Therapeutics and Preventative Measures.Biomedical materials & devices (New York, N.Y.) · 2025Article
- Zwitterion nanocomposite hydrogels with bioactivity and anti-adhesion properties for rapid prevention of postoperative and recurrent adhesion.Materials today. Bio · 2025Article
- Injectable and Sprayable Thermoresponsive Hydrogel with Fouling-Resistance as an Effective Barrier to Prevent Postoperative Cardiac Adhesions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- An Integrated Janus Patch with Asymmetric Tissue Adhesion for Enhanced Postoperative Adhesion Prevention.Polymer science & technology (Washington, D.C.) · 2025Article
- A Dual-Layer Hydrogel Barrier Integrating Bio-Adhesive and Anti-Adhesive Properties Prevents Postoperative Abdominal Adhesions.Advanced healthcare materials · 2025Article
- Radiotherapy plus a self-gelation powder encapsulating tRF5-GlyGCC inhibitor potentiates natural kill cell immunity to prevent hepatocellular carcinoma recurrence.Journal of nanobiotechnology · 2025Article
- A self-fused peptide-loaded hydrogel with injectability and tissue-adhesiveness for preventing postoperative peritoneal adhesions.Materials today. Bio · 2024Article
- An injectable and biodegradable zwitterionic gel for extending the longevity and performance of insulin infusion catheters.Nature biomedical engineering · 2024Article
- Article
- Poly(Glutamic Acid-Lysine) Hydrogels with Alternating Sequence Resist the Foreign Body Response in Rodents and Non-Human Primates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- What else should hemostatic materials do beyond hemostasis: A review.Materials today. Bio · 2024Review
- Chitosan-crosslinked polyvinyl alcohol anti-swelling hydrogel designed to prevent abdominal wall adhesion.Materials today. Bio · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Postoperative adhesions are most common issues for almost any types of abdominal and pelvic surgery, leading to adverse consequences. Pharmacological treatments and physical barrier devices are two main approaches to address postoperative adhesions but can only alleviate or reduce adhesions to some extent. There is an urgent need for a reliable approach to completely prevent postoperative adhesions and to significantly improve the clinical outcomes, which, however, is unmet with current technologies. Here we report that by applying a viscous, cream-like yet injectable zwitterionic polymer solution to the traumatized surface, postoperative adhesion was completely and reliably prevented in three clinically relevant but increasingly challenging models in rats. The success rate of full prevention is over 93% among 42 animals tested, which is a major leap in antiadhesion performance. Clinically used Interceed film can hardly prevent the adhesion in any of these models. Unlike current antiadhesion materials serving solely as physical barriers, the "nonfouling" zwitterionic polymer functioned as a protective layer for antiadhesion applications with the inherent benefit of resisting protein/cell adhesions. The nonfouling nature of the polymer prevented the absorption of fibronectins and fibroblasts, which contribute to the initial and late-stage development of the adhesion, respectively. This is the key working mechanism that differentiated our "complete prevention" approach from current underperforming antiadhesion materials. This work implies a safe, effective, and convenient way to fully prevent postoperative adhesions suffered by current surgical patients.
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Registered trials
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