Evidence map›Paper›PMID 33257536›Full record

ArticleInfection and immunity2021

STAT3 Promotes Schistosome-Induced Liver Injury by Inflammation, Oxidative Stress, Proliferation, and Apoptosis Signal Pathway.

Jie Zhao, Xin Liu, Yao Chen, Lin-Shuang Zhang, Ya-Rong Zhang, Deng-Ren Ji, Shi-Meng Liu, Mo-Zhi Jia, Yong-Hong Zhu, Yong-Fen Qi and 2 more

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  8. Aqueous extract ofFrontiers in pharmacology · 2023
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  9. Article
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  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jie ZhaoDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University, Beijing, China.
Xin LiuDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University, Beijing, China.
Yao ChenDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University, Beijing, China.
Lin-Shuang ZhangDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University, Beijing, China.
Ya-Rong ZhangDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University, Beijing, China.
Deng-Ren JiDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University, Beijing, China.
Shi-Meng LiuDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University, Beijing, China.
Mo-Zhi JiaDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University, Beijing, China.
Yong-Hong ZhuDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University, Beijing, China.
Yong-Fen QiDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University, Beijing, China.
Feng-Min LuDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University, Beijing, China.
Yan-Rong YuDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University, Beijing, China yuyr@bjmu.edu.cn.ORCID 0000-0002-1025-9409
Peking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schistosomiasis is a parasitic helminth disease that can cause organ lesions leading to health damage. During a schistosome infection, schistosome eggs can flow into the liver along the portal vein. Numerous inflammatory cells gather around the eggs, causing granulomas and fibrosis in the liver. In this process, many molecules are involved in the initiation and regulation of the fibrous scar formation. However, the precise molecular mechanisms responsible for the progression of granuloma formation and fibrosis initiation caused by schistosome infection have not been extensively studied. In this study, C57BL/6 wild-type mice and

Indexed as

AnimalsApoptosisCell ProliferationInflammationLiver CirrhosisOxidative StressSchistosoma japonicumSchistosomiasis japonicaSTAT3 Transcription FactorSTAT3 Transcription Factorapoptosisinflammationliver injuryoxidative stressproliferationS. japonicumSTAT3

Identifiers

PMID33257536
PMCPMC8097265
OpenAlexW3108680658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.