SynthesisThe British journal of general practice : the journal of the Royal College of General Practitioners2021
Impact of multimorbidity on healthcare costs and utilisation: a systematic review of the UK literature.
Synthesis in The British journal of general practice : the journal of the Royal College of General Practitioners, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
189 citing papers in PubMed, 13 syntheses or guidelines pooled it.
- Self-care needs in an aged population living with a chronic condition or multimorbidity: a systematic review.BMC geriatrics · 2026Pooled it
- Effectiveness of interventions for the management of multimorbidity in primary care and community settings: systematic review and meta-analysis.Family practice · 2025Pooled it
- Capacity building models for managing multiple long-term conditions in low-and-middle-income countries: a systematic review and gap analysis.Human resources for health · 2025Pooled it
- Comorbidities in the idiopathic pulmonary fibrosis and progressive pulmonary fibrosis trial population: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Age-Friendly Healthcare: An Evolutionary Concept Analysis.Journal of clinical nursing · 2024Pooled it
- The impact of adverse childhood experiences on multimorbidity: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Pooled it
- Modifiable risk factors that may be addressed in routine care to prevent progression to and extension of multimorbidity in people with COPD: a systematic literature review.BMJ open respiratory research · 2024Pooled it
- The effects of community interventions on unplanned healthcare use in patients with multimorbidity: a systematic review.Journal of the Royal Society of Medicine · 2024Pooled it
- Social determinants of multimorbidity patterns: A systematic review.Frontiers in public health · 2023Pooled it
- Depression and unplanned secondary healthcare use in patients with multimorbidity: A systematic review.PloS one · 2022Pooled it
- Ethnic Inequalities in Healthcare Use and Care Quality among People with Multiple Long-Term Health Conditions Living in the United Kingdom: A Systematic Review and Narrative Synthesis.International journal of environmental research and public health · 2021Pooled it
- Multimorbidity in Latin America and the Caribbean: a systematic review and meta-analysis.BMJ open · 2021Pooled it
- PACE-It: An Integrated Multidisciplinary Technology-Assisted Approach to Person-Centered Care for Individuals with Complex Care Needs.Journal of general internal medicine · 2026Trial
- Personalised exercise-rehabilitation for people with multiple long-term conditions (PERFORM): a randomised feasibility study.BMJ open · 2025Trial
- Trial
- Cost-effectiveness of a structured medication review approach for multimorbid older adults: Within-trial analysis of the OPERAM study.PloS one · 2022Trial
- Healthcare utilization and chronic condition clusters in multimorbidity patients using weighted k-means: a register-based study in Denmark.Health information science and systems · 2026Article
- RSV-related hospital admissions in a subset of hospitals in England and Scotland: A real-world study (2018-2023).Human vaccines & immunotherapeutics · 2026Article
- Front-line decision-making: a thematic analysis of interviews with hospital staff on referrals, admissions, and care for people with multiple long-term conditions.BMC medicine · 2026Article
129 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundManaging multimorbidity is complex for both patients and healthcare systems. Patients with multimorbidity often use a variety of primary and secondary care services. Country-specific research exploring the healthcare utilisation and cost consequences of multimorbidity may inform future interventions and payment schemes in the UK.
aimTo assess the relationship between multimorbidity, healthcare costs, and healthcare utilisation; and to determine how this relationship varies by disease combinations and healthcare components. DESIGN AND
settingA systematic review.
methodThis systematic review followed the bidirectional citation searching to completion method. MEDLINE and grey literature were searched for UK studies since 2004. An iterative review of references and citations was completed. Authors from all articles selected were contacted and asked to check for completeness of UK evidence. The National Institutes of Health National Heart, Lung, and Blood Institute quality assessment tool was used to assess risk of bias. Data were extracted, findings synthesised, and study heterogeneity assessed; meta-analysis was conducted when possible.
resultsSeventeen studies were identified: seven predicting healthcare costs and 10 healthcare utilisation. Multimorbidity was found to be associated with increased total costs, hospital costs, care transition costs, primary care use, dental care use, emergency department use, and hospitalisations. Several studies demonstrated the high cost of depression and of hospitalisation associated with multimorbidity.
conclusionIn the UK, multimorbidity increases healthcare utilisation and costs of primary, secondary, and dental care. Future research is needed to examine whether integrated care schemes offer efficiencies in healthcare provision for multimorbidity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.