ArticleJournal of the American Medical Directors Association2020
Clinical Suspicion of COVID-19 in Nursing Home Residents: Symptoms and Mortality Risk Factors.
Article in Journal of the American Medical Directors Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Clinical expressions, characteristics and treatments of confirmed COVID-19 in nursing home residents: a systematic review.BMC geriatrics · 2023Pooled it
- Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.The Cochrane database of systematic reviews · 2022Pooled it
- Parkinson's disease and COVID-19: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- A meta-analysis on the risk factors adjusted association between cardiovascular disease and COVID-19 severity.BMC public health · 2021Pooled it
- Parkinson's disease may worsen outcomes from coronavirus disease 2019 (COVID-19) pneumonia in hospitalized patients: A systematic review, meta-analysis, and meta-regression.Parkinsonism & related disorders · 2021Pooled it
- Charlson comorbidity index has no incremental value for mortality risk prediction in nursing home residents with COVID-19 disease.BMC geriatrics · 2025Observational
- Enhancing Standardized and Structured Recording by Elderly Care Physicians for Reusing Electronic Health Record Data: Interview Study.JMIR medical informatics · 2024Article
- The effect of current antithrombotic therapy on mortality in nursing home residents with COVID-19: a multicentre retrospective cohort study.Age and ageing · 2024Article
- Drivers of COVID-19 Outcomes in Long-Term Care Facilities Using Multi-Level Analysis: A Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
- How the Timing of Annual COVID-19 Vaccination of Nursing Home Residents and Staff Affects Its Value.Journal of the American Medical Directors Association · 2024Article
- Article
- Atypical Presentation of COVID-19 in Older Adults: A Scoping Review.Portuguese journal of public health · 2023Article
- Moral lessons from residents, close relatives and volunteers about the COVID-19 restrictions in Dutch and Flemish nursing homes.Philosophy, ethics, and humanities in medicine : PEHM · 2023Article
- A study protocol of external validation of eight COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting.Diagnostic and prognostic research · 2023Article
- Older patients with COVID-19 and neuropsychiatric conditions: A study of risk factors for mortality.Brain and behavior · 2022Observational
- Best practice approaches to outpatient management of people living with Parkinson's disease during the COVID-19 pandemic.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- COVID-19 in French nursing homes during the second pandemic wave: a mixed-methods cross-sectional study.BMJ open · 2022Article
- Self-Assessed Severity as a Determinant of Coronavirus Disease 2019 Symptom Specificity: A Longitudinal Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Coronavirus Disease-2019 in Older People with Cognitive Impairment.Clinics in geriatric medicine · 2022Review
- Short- and Long-Term Mortality and Mortality Risk Factors among Nursing Home Patients after COVID-19 Infection.Journal of the American Medical Directors Association · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo describe the symptomatology, mortality, and risk factors for mortality in a large group of Dutch nursing home (NH) residents with clinically suspected COVID-19 who were tested with a reverse transcription-polymerase chain reaction (RT-PCR) test.
designProspective cohort study. SETTING AND
participantsResidents of Dutch NHs with clinically suspected COVID-19 and who received RT-PCR test.
methodsWe collected data of NH residents with clinically suspected COVID-19 via electronic health records between March 18 and May 13, 2020. Registration was performed on diagnostic status [confirmed (COVID-19+)/ruled out (COVID-19-)] and symptomatology (typical and atypical symptoms). Information on mortality and risk factors for mortality were extracted from usual care data.
resultsIn our sample of residents with clinically suspected COVID-19 (N = 4007), COVID-19 was confirmed in 1538 residents (38%). Although symptomatology overlapped between residents with COVID-19+ and COVID-19-, those with COVID-19+ were 3 times more likely to die within 30 days [hazard ratio (HR), 3.1, 95% confidence interval (CI) 2.7-3.6]. Within this group, mortality was higher for men than for women (HR 1.8, 95% CI 1.5-2.2), and we observed a higher mortality for residents with dementia, reduced kidney function, and Parkinson's disease, even when corrected for age, gender, and comorbidities. CONCLUSIONS AND IMPLICATIONS: About 40% of the residents with clinically suspected COVID-19 actually had COVID-19, based on the RT-PCR test. Despite an overlap in symptomatology, mortality rate was 3 times higher for residents with COVID-19+. This emphasizes the importance of using low-threshold testing in NH residents, which is an essential prerequisite to using limited personal protective equipment and isolation measures efficiently.
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