Evidence map›Paper›PMID 33256863›Full record

ArticleEpidemiology and infection2020

High MERS-CoV seropositivity associated with camel herd profile, husbandry practices and household socio-demographic characteristics in Northern Kenya.

I Ngere, P Munyua, J Harcourt, E Hunsperger, N Thornburg, M Muturi, E Osoro, J Gachohi, B Bodha, B Okotu and 5 more

Abstract read
In one paragraph

Article in Epidemiology and infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

I NgereWashington State University Global Health Program, Nairobi, Kenya.ORCID 0000-0002-6688-3390
P MunyuaDivision of Global Health Protection, US Centers for Disease Control and Prevention-Kenya, Nairobi, Kenya.
J HarcourtDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
E HunspergerDivision of Global Health Protection, US Centers for Disease Control and Prevention-Kenya, Nairobi, Kenya.
N ThornburgDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
M MuturiKenya Ministry of Agriculture Livestock and Fisheries, Zoonotic Disease Unit, Nairobi, Kenya.
E OsoroWashington State University Global Health Program, Nairobi, Kenya.
J GachohiWashington State University Global Health Program, Nairobi, Kenya.
B BodhaDepartment of Veterinary and Livestock, County Government of Marsabit, Marsabit, Kenya.
B OkotuDepartment of Veterinary Services, County Government of Marsabit, Marsabit, Kenya.
J OyugiDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya.
W JaokoDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya.
A MwatondoKenya Ministry of Health, Zoonotic Disease Unit, Nairobi, Kenya.
K NjengaWashington State University Global Health Program, Nairobi, Kenya.
M A WiddowsonDivision of Global Health Protection, US Centers for Disease Control and Prevention-Kenya, Nairobi, Kenya.

Funding

Zoonotic and Emerging Infectious Diseases Training ProgramD43TW011519 · FIC · WASHINGTON STATE UNIVERSITY · PI Walter Godfrey Jaoko, Thumbi Mwangi · 2020 to 2026
$1.2M
CGH CDC HHS U01 GH002143FIC NIH HHS D43 TW011519
6 · The paper itself

Abstract

Despite high exposure to Middle East respiratory syndrome coronavirus (MERS-CoV), the predictors for seropositivity in the context of husbandry practices for camels in Eastern Africa are not well understood. We conducted a cross-sectional survey to describe the camel herd profile and determine the factors associated with MERS-CoV seropositivity in Northern Kenya. We enrolled 29 camel-owning households and administered questionnaires to collect herd and household data. Serum samples collected from 493 randomly selected camels were tested for anti-MERS-CoV antibodies using a microneutralisation assay, and regression analysis used to correlate herd and household characteristics with camel seropositivity. Households reared camels (median = 23 camels and IQR 16-56), and at least one other livestock species in two distinct herds; a home herd kept near homesteads, and a range/fora herd that resided far from the homestead. The overall MERS-CoV IgG seropositivity was 76.3%, with no statistically significant difference between home and fora herds. Significant predictors for seropositivity (P ⩽ 0.05) included camels 6-10 years old (aOR 2.3, 95% CI 1.0-5.2), herds with ⩾25 camels (aOR 2.0, 95% CI 1.2-3.4) and camels from Gabra community (aOR 2.3, 95% CI 1.2-4.2). These results suggest high levels of virus transmission among camels, with potential for human infection.

Indexed as

CamelusMiddle East Respiratory Syndrome CoronavirusAdultAge FactorsAnimal HusbandryAnimalsAntibodies, NeutralizingAntibodies, ViralCoronavirus InfectionsCross-Sectional StudiesEducational StatusFamily CharacteristicsFemaleHumansKenyaMaleAntibodies, NeutralizingAntibodies, ViralKenyaMiddle East respiratory syndrome coronavirusnomadic communitiesseroprevalencezoonoses

Identifiers

PMID33256863
PMCPMC7737118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.