ArticleArthritis research & therapy2020
Refinement and validation of infrared thermal imaging (IRT): a non-invasive technique to measure disease activity in a mouse model of rheumatoid arthritis.
Article in Arthritis research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 32 citations in OpenAlex.
- Efficient genetic perturbation of murine sensory neurons in vivo using CRISPR/Cas9.The journal of pain · 2026Article
- Texture-enhanced thermography for joint inflammation detection using consumer-grade thermal cameras.PloS one · 2026Article
- Efficient genetic perturbation of murine sensory neuronsbioRxiv : the preprint server for biology · 2025Article
- Comparing thermographic heat signatures with joint inflammation detected by ultrasound at the knees in patients with rheumatoid arthritis.Scientific reports · 2025Article
- Single-camera motion capture of finger joint mobility as a digital biomarker for disease activity in rheumatoid arthritis.Rheumatology advances in practice · 2025Article
- [Application and prospects of infrared thermography in rheumatic diseases].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Review
- Prodrug Nanomedicine for Synovium Targeted Therapy of Inflammatory Arthritis: Insights from Animal Model and Human Synovial Joint Fluid.Advanced healthcare materials · 2024Article
- Understanding Ultrasound Power Doppler Synovitis at Clinically Quiescent Joints and Thermographic Joint Inflammation Assessment in Patients with Rheumatoid Arthritis.Diagnostics (Basel, Switzerland) · 2024Article
- Effects of exogenous deoxyribonuclease I in collagen antibody-induced arthritis.Journal of inflammation (London, England) · 2024Article
- Power-integrated, wireless neural recording systems on the cranium using a direct printing method for deep-brain analysis.Science advances · 2024Article
- Effects of meridian sinew tuina after identifying the treatment area under ultrasound localization combined with greater and third occipital nerve injections in cervicogenic headache: a randomized controlled trial protocol.Frontiers in neurology · 2024Article
- Sex differences in long-term effects of collagen-induced arthritis in middle-aged mice.Frontiers in physiology · 2023Article
- Preclinical evaluation and pilot clinical study of [European journal of nuclear medicine and molecular imaging · 2022Article
- The Value of Thermal Imaging for Knee Arthritis: A Single-Center Observational Study.Yonsei medical journal · 2022Observational
- IRimage: open source software for processing images from infrared thermal cameras.PeerJ. Computer science · 2022Article
- Experimental Applications and Factors Involved in Validating Thermal Windows Using Infrared Thermography to Assess the Health and Thermostability of Laboratory Animals.Animals : an open access journal from MDPI · 2021Review
- An Anatomical Thermal 3D Model in Preclinical Research: Combining CT and Thermal Images.Sensors (Basel, Switzerland) · 2021Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe discovery and development of new medicines requires high-throughput screening of possible therapeutics in a specific model of the disease. Infrared thermal imaging (IRT) is a modern assessment method with extensive clinical and preclinical applications. Employing IRT in longitudinal preclinical setting to monitor arthritis onset, disease activity and therapeutic efficacies requires a standardized framework to provide reproducible quantitative data as a precondition for clinical studies.
methodsHere, we established the accuracy and reliability of an inexpensive smartphone connected infrared (IR) camera against known temperature objects as well as certified blackbody calibration equipment. An easy to use protocol incorporating contactless image acquisition and computer-assisted data analysis was developed to detect disease-related temperature changes in a collagen-induced arthritis (CIA) mouse model and validated by comparison with two conventional methods, clinical arthritis scoring and paw thickness measurement. We implemented IRT to demonstrate the beneficial therapeutic effect of nanoparticle drug delivery versus free methotrexate (MTX) in vivo.
resultsThe calibrations revealed high accuracy and reliability of the IR camera for detecting temperature changes in the rheumatoid arthritis animal model. Significant positive correlation was found between temperature changes and paw thickness measurements as the disease progressed. IRT was found to be superior over the conventional techniques specially at early arthritis onset, when it is difficult to observe subclinical signs and measure structural changes.
conclusionIRT proved to be a valid and unbiased method to detect temperature changes and quantify the degree of inflammation in a rapid and reproducible manner in longitudinal preclinical drug efficacy studies.
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