Evidence map›Paper›PMID 33256790›Full record

ArticleReproductive health2020

Evaluating the effect of care around labor and delivery practices on early neonatal mortality in the Global Network's Maternal and Newborn Health Registry.

Archana B Patel, Elizabeth M Simmons, Sowmya R Rao, Janet Moore, Tracy L Nolen, Robert L Goldenberg, Shivaprasad S Goudar, Manjunath S Somannavar, Fabian Esamai, Paul Nyongesa and 12 more

Registry-linked trialAbstract read
In one paragraph

Article in Reproductive health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01073475 (Global Network for Women's and Children's Health Research Maternal Newborn Health Registry), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01073475 recruitingnot on this map

Global Network for Women's and Children's Health Research Maternal Newborn Health Registry

TypeobservationalSponsorNICHD Global Network for Women's and Children's HealthRan2008 to 2030Enrolled950,000ConditionsPregnancy Outcome Trends in Low-resource Geographic AreasArmsThere is no intervention associated with the parent MNHR study. For the MNHR COVID sub-study, participants will be asked to provide a blood specimen at or near delivery.
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Archana B PatelLata Medical Research Foundation, Nagpur, India. dr_apatel@yahoo.com.
Elizabeth M SimmonsSchool of Public Health, Boston University, Boston, MA, USA.
Sowmya R RaoSchool of Public Health, Boston University, Boston, MA, USA.
Janet MooreRTI International, Durham, NC, USA.
Tracy L NolenRTI International, Durham, NC, USA.
Robert L GoldenbergDepartment of Obstetrics and Gynecology, Columbia University School of Medicine, New York, NY, USA.
Shivaprasad S GoudarKLE Academy Higher Education and Research, J N Medical College, Belagavi, Karnataka, India.
Manjunath S SomannavarKLE Academy Higher Education and Research, J N Medical College, Belagavi, Karnataka, India.
Fabian EsamaiMoi University School of Medicine, Eldoret, Kenya.
Paul NyongesaMoi University School of Medicine, Eldoret, Kenya.
Ana L GarcesInstituto de Nutrición de Centroamérica y Panamá, Guatemala City, Guatemala.
Elwyn ChombaUniversity Teaching Hospital, Lusaka, Zambia.
Musaku MwenechanyaUniversity Teaching Hospital, Lusaka, Zambia.
Sarah SaleemAga Khan University, Karachi, Pakistan.
Farnaz NaqviAga Khan University, Karachi, Pakistan.
Melissa BausermanUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sherri BucherUniversity of Indiana, Indianapolis, IN, USA.
Nancy F KrebsUniversity of Colorado School of Medicine, Denver, CO, USA.
Richard J DermanThomas Jefferson University, Philadelphia, USA.
Waldemar A CarloUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Marion Elizabeth M Koso-ThomasMcClureRTI International, Durham, NC, USA.
Patricia L HibberdSchool of Public Health, Boston University, Boston, MA, USA.

Funding

Boston University/Lata Medical Research Foundation Global Network for Women's Children's Health Research UnitUG1HD078439 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Patricia L Hibberd · 2018 to 2026
$5.5M
Nutrition-specific interventions to improve long-term maternal-child health outcomesUG1HD076474 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Edwin Jose Asturias, NANCY F KREBS · 2018 to 2026
$5.4M
Global Network for Women's and Children's Health ResearchUG1HD076461 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI BUCHER, SHERRI LYNN, SZYLD, EDGARDO GABRIEL · 2018 to 2023
$3.2M
NICHD NIH HHS UG1 HD076461NICHD NIH HHS UG1 HD076474NICHD NIH HHS UG1 HD078439
6 · The paper itself

Abstract

backgroundNeonatal deaths in first 28-days of life represent 47% of all deaths under the age of five years globally and are a focus of the United Nation's (UN's) Sustainable Development Goals. Pregnant women are delivering in facilities but that does not indicate quality of care during delivery and the postpartum period. The World Health Organization's Essential Newborn Care (ENC) package reduces neonatal mortality, but lacks a simple and valid composite index that measures its effectiveness.

methodsData on 5 intra-partum and 3 post-partum practices (indicators) recommended as part of ENC, routinely collected in NICHD's Global Network's (GN) Maternal Newborn Health Registry (MNHR) between 2010 and 2013, were included. We evaluated if all 8 practices (Care around Delivery - CAD), combined as an index was associated with reduced early neonatal mortality rates (days 0-6 of life).

resultsA total of 150,848 live births were included in the analysis. The individual indicators varied across sites. All components were present in 19.9% births (range 0.4 to 31% across sites). Present indicators (8 components) were associated with reduced early neonatal mortality [adjusted RR (95% CI):0.81 (0.77, 0.85); p < 0.0001]. Despite an overall association between CAD and early neonatal mortality (RR < 1.0 for all early mortality): delivery by skilled birth attendant; presence of fetal heart and delayed bathing were associated with increased early neonatal mortality.

conclusionsPresent indicators (8 practices) of CAD were associated with a 19% reduction in the risk of neonatal death in the diverse health facilities where delivery occurred within the GN MNHR. These indicators could be monitored to identify facilities that need to improve compliance with ENC practices to reduce preventable neonatal deaths. Three of the 8 indicators were associated with increased neonatal mortality, due to baby being sick at birth. Although promising, this composite index needs refinement before use to monitor facility-based quality of care in association with early neonatal mortality. Trial registration The identifier of the Maternal Newborn Health Registry at ClinicalTrials.gov is NCT01073475.

Indexed as

Infant HealthLabor, ObstetricPerinatal DeathPostnatal CarePrenatal CareQuality of Health CareChild, PreschoolFemaleHumansInfantInfant MortalityInfant, NewbornPregnancyRegistriesComposite indexEarly neonatal mortalityEarly neonatal periodEssential newborn careGlobal networkIntrapartum careLabor and delivery careLower middle-income countriesLow income countriesNeonatal mortalityNewborn carePostpartum careQuality of care

Identifiers

PMID33256790
PMCPMC7708898

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.