Evidence map›Paper›PMID 33256741›Full record

ArticleJournal of nanobiotechnology2020

Development of fluorescence/MR dual-modal manganese-nitrogen-doped carbon nanosheets as an efficient contrast agent for targeted ovarian carcinoma imaging.

Cuiping Han, Ting Xie, Keying Wang, Shang Jin, Ke Li, Peipei Dou, Nana Yu, Kai Xu

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. MnCOTheranostics · 2022
    Article
  7. Radiopharmaceutical and EuJournal of nanobiotechnology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cuiping HanSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China. hancp@xzhmu.edu.cn.ORCID http://orcid.org/0000-0002-5490-2216
Ting XieSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China.
Keying WangDepartment of Medical Imaging, Jinshan Hospital Affiliated To Fudan University, Shnghai, 200540, China.
Shang JinSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China.
Ke LiSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China.
Peipei DouSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China.
Nana YuSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China.
Kai XuDepartment of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221004, China. xkpaper@163.com.
Xuzhou Medical College · CNJinshan Hospital of Fudan University · CN

Funding

China Postdoctoral Science Foundation funded project 2016M591923China Postdoctoral Science Foundation funded project 2017T100405Jiangsu Postdoctoral Science Foundation funded project 1601189CNational Natural Science Foundation of China 81671744National Natural Science Foundation of China 81771904the Peak of Six Talents of Jiangsu Province WSW-051the project of Invigorating Health Care through Science, Technology and Education, Jiangsu Provincial Medical Youth Talent QNRC2016782
6 · The paper itself

Abstract

backgroundDevelopment of sensitive and specific imaging approaches for the detection of ovarian cancer holds great promise for improving the therapeutic efficacy and the lifespan of the patients.

resultsIn this study, manganese-nitrogen doped carbon nanosheets (Mn-N-CNSs) coupled with Anti-HE4 monoclonal antibody (Mn-N-CNSs@Anti-HE4) were synthesized for the specific and targeted fluorescence/MR dual-modal imaging of ovarian carcinoma. The prepared Mn-N-CNSs revealed excellent aqueous dispersity, good colloidal stability, great optical properties and high longtudinal relaxivity rate (r

conclusionThe prepared Mn-N-CNSs@Anti-HE4 with excellent biocompatibility, high-performance and superior tumor-targeting ability provides a novel fluorescence/MR dual-modal nanoprobe for specific labeling and detection of ovarian carcinoma cells in vitro and in vivo.

Indexed as

Contrast MediaFluorescent DyesNanoparticlesAnimalsCarbonCell Line, TumorCell SurvivalFemaleMagnetic Resonance ImagingManganeseMiceNIH 3T3 CellsNitrogenOvarian NeoplasmsSpectrometry, FluorescenceCarbonContrast MediaFluorescent DyesManganeseNitrogenCarbon nanosheetsFluorescence/mr dual-modal nanoprobeManganeseTumor targeting

Identifiers

PMID33256741
PMCPMC7708123
OpenAlexW3109204691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.