Evidence map›Paper›PMID 33256661›Full record

ArticleBMC ophthalmology2020

Associations of serum uric acid and urinary albumin with the severity of diabetic retinopathy in individuals with type 2 diabetes.

Donghe Chen, Xiufang Sun, Xinxin Zhao, Ying Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Donghe ChenDepartment of Endocrinology, Daqing People's Hospital, the Fifth Affiliated Hospital of Harbin Medical University, No.213, Jianshe Road, Development zone, Daqing, 163000, China.
Xiufang SunDepartment of Endocrinology, the First Affiliated Hospital of Qiqihar Medical University, Qiqihar, 161041, China.
Xinxin ZhaoDepartment of Endocrinology, the First Hospital of Suihua, No. 180 Beilin Road, Beilin District, Suihua, 152000, China. 13945500835@163.com.
Ying LiuDepartment of Endocrinology, Daqing People's Hospital, the Fifth Affiliated Hospital of Harbin Medical University, No.213, Jianshe Road, Development zone, Daqing, 163000, China. daqingyingl66@163.com.
Harbin Medical University · CNQiqihar Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic retinopathy (DR) is a serious microvascular complication of type 2 diabetes mellitus (T2DM). The aim of this retrospective study was to reveal the risk factors for the severity of DR in individuals with T2DM. Demographic data and biochemical parameters were collected and analyzed.

methodsA total of 518 individuals with type 2 diabetes were included. These individuals were classified into three groups according to the severity of diabetic retinopathy: non-diabetic retinopathy (NDR) group (N = 172), non proliferative diabetic retinopathy (NPDR) group (N = 184), and proliferative diabetic retinopathy (PDR) group (N = 162). Demographic and clinical measurement data of the individuals were collected by reviewing medical records and direct interview. The demographic data and biochemical parameters between groups were compared using Student's t-test. Moreover, the factors related to severity of diabetic retinopathy were identified by using the multivariate logistic regression analysis.

resultsNo significant difference in age, gender, body mass index (BMI), and diabetes duration was found among these three groups. The serum uric acid (SUA), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), homocysteine, and urinary albumin levels were significantly higher in the NPDR and PDR group than those in the NDR group (P < 0.05). The individuals in the PDR group had obviously higher levels of SUA, homocysteine, and urinary albumin than individuals in the NPDR group (P < 0.05). The multivariate logistic regression analysis revealed that high SUA, homocysteine, TC, LDL-c, and urinary albumin levels were associated with more serious diabetic retinopathy (OR > 1; P < 0.05).

conclusionThe concentrations of SUA and urinary albumin are associated with the severity of DR in individuals with T2DM.

Indexed as

Diabetes Mellitus, Type 2Diabetic RetinopathyAlbuminsHumansRetrospective StudiesUric AcidAlbuminsUric AcidDiabetic retinopathySerum uric acidType 2 diabetes mellitusUrinary albumin

Identifiers

PMID33256661
PMCPMC7706232
OpenAlexW3107188436

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.